(11R,15S)-13-((1S,2S)-1-phenyl-1,3-bis((2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy)propan-2-yl)-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-dione | 1172594-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (11R,15S)-13-((1S,2S)-1-phenyl-1,3-bis((2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy)propan-2-yl)-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-dione
• CAS: 1172594-72-7
• 化学式: C₈₃H₁₀₁NO₈P₂
• 分子量: 1302.66
• InChiKey: WSTLWPQRMGXIMU-MCEGJQAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  22.83
• 重原子数：
  94.0
• 可旋转键数：
  8.0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  108.4
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  (11R,15S)-13-((1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl)-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-dione 、 3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl phosphorochloridite 在 吡啶 作用下， 以80%的产率得到(11R,15S)-13-((1S,2S)-1-phenyl-1,3-bis((2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy)propan-2-yl)-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-dione
  参考文献：
  名称：

  New chiral diphosphites derived from substituted 9,10-dihydroanthracene. Applications in asymmetric catalytic processes

  摘要：

  Two novel diphosphite ligands derived from 9,10-dihydroanthracene originating from a 1,3-diol chiral fragment, have been prepared in high yields from readily available starting materials. Rhodium and palladium catalytic systems containing these new P-donor ligands led to 51% and 90% ee in asymmetric hydroformylation and allylic alkylation processes, respectively. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.02.052
• 作为试剂：
  描述：

  1,3-二苯基-2-丙烯基乙酸酯 、 丙二酸二甲酯 在 N,O-双三甲硅基乙酰胺 、 bis(η3-allyl-μ-chloropalladium(II)) 、 (11R,15S)-13-((1S,2S)-1-phenyl-1,3-bis((2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy)propan-2-yl)-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-dione 、 potassium acetate 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以93%的产率得到(S)-dimethyl 2-(1,3-diphenylallyl)malonate
  参考文献：
  名称：

  New chiral diphosphites derived from substituted 9,10-dihydroanthracene. Applications in asymmetric catalytic processes

  摘要：

  Two novel diphosphite ligands derived from 9,10-dihydroanthracene originating from a 1,3-diol chiral fragment, have been prepared in high yields from readily available starting materials. Rhodium and palladium catalytic systems containing these new P-donor ligands led to 51% and 90% ee in asymmetric hydroformylation and allylic alkylation processes, respectively. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.02.052