N-(S)-(1-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(3,5-difluorophenyl)-4,4,4-trifluoro-1-oxobutan-2-yl)-5-chloro-thiophene-2-sulfonamide | 1104029-29-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(S)-(1-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(3,5-difluorophenyl)-4,4,4-trifluoro-1-oxobutan-2-yl)-5-chloro-thiophene-2-sulfonamide
• 英文别名: N-[(2S)-1-[(4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(3,5-difluorophenyl)-4,4,4-trifluoro-1-oxobutan-2-yl]-5-chlorothiophene-2-sulfonamide
• CAS: 1104029-29-9
• 化学式: C₂₄H₁₈ClF₅N₂O₅S₂
• 分子量: 608.994
• InChiKey: OGSNNPNIIVIVBZ-ZPWCZAOQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  N-(S)-(1-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(3,5-difluorophenyl)-4,4,4-trifluoro-1-oxobutan-2-yl)-5-chloro-thiophene-2-sulfonamide 在 锂硼氢 、 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以14%的产率得到5-chloro-N-((2S,3R)-3-(3,5-difluorophenyl)-4,4,4-trifluoro-1-hydroxybutan-2-yl)thiophene-2-sulfonamide
  参考文献：
  名称：

  INHIBITORS OF BETA AMYLOID PRODUCTION

  摘要：

  描述了在与β-淀粉样蛋白产生相关的疾病治疗中有用的新型磺胺化合物，以及它们的制备途径。这些磺胺化合物具有以下结构，其中R1-R3在此定义。还提供了含有这些化合物和/或这些化合物的前药以及与生理兼容载体的药物组合物。这些化合物特别适用于抑制β淀粉样蛋白的产生，并治疗阿尔茨海默病、淀粉样血管病、脑淀粉样血管病、全身淀粉样病、荷兰型遗传性脑出血伴有淀粉样蛋白沉积、包涵体肌炎、轻度认知障碍（MCI）和唐氏综合征。

  公开号：

  US20090023801A1
• 作为产物：
  描述：

  5-氯噻唑-2-磺酰氯 、 (4S)-3-(2-(S)-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以51%的产率得到N-(S)-(1-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(3,5-difluorophenyl)-4,4,4-trifluoro-1-oxobutan-2-yl)-5-chloro-thiophene-2-sulfonamide
  参考文献：
  名称：

  INHIBITORS OF BETA AMYLOID PRODUCTION

  摘要：

  描述了在与β-淀粉样蛋白产生相关的疾病治疗中有用的新型磺胺化合物，以及它们的制备途径。这些磺胺化合物具有以下结构，其中R1-R3在此定义。还提供了含有这些化合物和/或这些化合物的前药以及与生理兼容载体的药物组合物。这些化合物特别适用于抑制β淀粉样蛋白的产生，并治疗阿尔茨海默病、淀粉样血管病、脑淀粉样血管病、全身淀粉样病、荷兰型遗传性脑出血伴有淀粉样蛋白沉积、包涵体肌炎、轻度认知障碍（MCI）和唐氏综合征。

  公开号：

  US20090023801A1

文献信息

• Propylene Copolymers in Elastomeric Compositions
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20150021816A1

  公开（公告）日：2015-01-22

  Disclosed is an ethylene-propylene copolymer having isotactic polypropylene crystallinity compounded with a halobutyl rubber in an amount effective to improve one or more of aged tensile strength retention, fatigue resistance, and dimensional stability. Also disclosed is an elastomer composition wherein the copolymer can have at least 60 wt % propylene-derived units and at least 6 wt % ethylene-derived units, and a tire inner tube or tire innerliner composition comprising from 1 to 10 phr copolymer. Also disclosed is a vulcanizate of the elastomer composition, and articles, tire innerliners, tires, and tire inner tubes comprising the vulcanizate. Further disclosed are processes for making molded articles, tire inner tubes and tires.
• US9469753B2
  申请人：——

  公开号：US9469753B2

  公开（公告）日：2016-10-18
• [EN] INHIBITORS OF BETA AMYLOID PRODUCTION<br/>[FR] INHIBITEURS DE PRODUCTION DE BÊTA AMYLOÏDE
  申请人：WYETH CORP

  公开号：WO2009012205A1

  公开（公告）日：2009-01-22

  Novel sulfonamide compounds useful in the treatment of conditions related to the production of beta-amyloid are described, as are routes to their preparation. The sulfonamide compounds are of the following structure, wherein R4-R3 are defined herein. Also provided are pharmaceutical compositions containing these compounds and/or prodrugs of these compounds and a physiologically compatible carrier. These compounds are specifically useful for inhibiting beta amyloid production, and treating Alzheimer's Disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome.
• [EN] ELASTOMERIC COMPOSITIONS HAVING IMPROVED PROPERTIES<br/>[FR] COMPOSITIONS ÉLASTOMÈRES AYANT DES PROPRIÉTÉS AMÉLIORÉES
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2010016981A1

  公开（公告）日：2010-02-11

  Elastomeric compositions comprising at least one C4 to C7 monoolefin elastomer, at least one polyalphaolefin, and optionally at least one hydrocarbon polymer additive are disclosed. The PAO comprises oligomers of one or more C2 to C20 alpha-olefins having a kinematic viscosity at 100°C of 3 to 3000 cSt and a Mw/Mn of less than 4. In one aspect, the elastomeric composition may have improved flex fatigue properties and have a fatigue life of 450,000 Kc or more as measured by ASTM D 412 die C. In another aspect, an elastomeric composition may have improved impermeability and have a permeation coefficient at 40°C of 160 cc*mm/(m2 -day) or less.
• INHIBITORS OF BETA AMYLOID PRODUCTION
  申请人：Caggiano Thomas J.

  公开号：US20090023801A1

  公开（公告）日：2009-01-22

  Novel sulfonamide compounds useful in the treatment of conditions related to the production of beta-amyloid are described, as are routes to their preparation. The sulfonamide compounds are of the following structure, wherein R 1 -R 3 are defined herein. Also provided are pharmaceutical compositions containing these compounds and/or prodrugs of these compounds and a physiologically compatible carrier. These compounds are specifically useful for inhibiting beta amyloid production, and treating Alzheimer's Disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome.

  描述了在与β-淀粉样蛋白产生相关的疾病治疗中有用的新型磺胺化合物，以及它们的制备途径。这些磺胺化合物具有以下结构，其中R1-R3在此定义。还提供了含有这些化合物和/或这些化合物的前药以及与生理兼容载体的药物组合物。这些化合物特别适用于抑制β淀粉样蛋白的产生，并治疗阿尔茨海默病、淀粉样血管病、脑淀粉样血管病、全身淀粉样病、荷兰型遗传性脑出血伴有淀粉样蛋白沉积、包涵体肌炎、轻度认知障碍（MCI）和唐氏综合征。