N’,2-bis(2-methoxybenzylidene)hydrazine-1-carbothiohydrazide | 51236-75-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N’,2-bis(2-methoxybenzylidene)hydrazine-1-carbothiohydrazide
• 英文别名: bis(o-methoxybenzaldehyde)-thiocarbodihydrazone；1,3-bis[(2-methoxyphenyl)methylideneamino]thiourea
• CAS: 51236-75-0
• 化学式: C₁₇H₁₈N₄O₂S
• 分子量: 342.422
• InChiKey: AWDGJZYDUCRIFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  99.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  硫代卡巴肼 、 邻甲氧基苯甲醛 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 以76 %的产率得到N’,2-bis(2-methoxybenzylidene)hydrazine-1-carbothiohydrazide
  参考文献：
  名称：

  Synthesis, in vitro bio-evaluation, and molecular docking study of thiosemicarbazone-based isatin/bis-Schiff base hybrid analogues as effective cholinesterase inhibitors

  摘要：

  DOI：

  10.1016/j.molstruc.2023.135351

文献信息

• Synthesizing New Hydrazone Derivatives and Studying their Effects on the Inhibition of Copper Corrosion in Sodium Chloride Solutions
  作者：El-Sayed M. Sherif、Ayman H. Ahmed

  DOI：10.1080/15533174.2010.492546

  日期：2010.7.19

  O-methoxybenzaldehydebenzoylhydrazone (O-MBH) and bis-(o-methoxybenzaldehyde)-thiocarbodihydrazone (O-MTH) were synthesized. The O-MBH and O-MTH effects on the inhibition of copper corrosion in 3.5% NaCl solution were investigated. Electrochemical measurements showed that the addition of O-MBH and O-MTH decreased the corrosion parameters of copper in the test solutions. The weight loss experiments indicated that O-MBH and O-MTH decreased the corrosion rate of copper. The data pointed out that O-MBH and O-MTH inhibit the copper corrosion in NaCl solution with inhibition efficiency in the order of O-MTH > O-MBH.