| 1211805-90-1

• 分子结构分类: 有机化合物
• CAS: 1211805-90-1
• 化学式: C₉₇H₁₅₇N₅O₇₄
• 分子量: 2577.3
• InChiKey: GNEMKUCICREMFR-OCEACLBPSA-N

反应信息

• 作为产物：
  描述：

  、 Fmoc-甘氨酸 、 Fmoc-L-丙氨酸 在 哌啶 、 吡啶 、 1,2-二氯乙烷 、 N,N-二异丙基乙胺 、 1-羟基苯并三唑 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以2.5%的产率得到
  参考文献：
  名称：

  Synthesis of bifunctional peptide derivatives based on a β-cyclodextrin core with drug delivery potential

  摘要：

  A selective, versatile, robust methodology for bifunctionalization of beta-cyclodextrin is achieved allowing the attachment of peptides in varying C- and/or N-terminal combinations on resin using Fmoc SPPS. Two linkers are attached to cyclodextrin enabling selective binding to the resin (or a peptide attached to the resin). Continuation of peptide growth and/or cleavage from the resin follows, thus various combinations of peptide-cyclodextrin species are achieved. A model peptide (Gly-Ala) is used in this study to illustrate the potential of this system for attaching one or more bioactive peptides for drug transport and release purposes. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.118