| 1350624-55-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1350624-55-3
• 化学式: C₂₄H₃₄N₄O₇
• 分子量: 490.557
• InChiKey: NBEXKNJPIUPDIT-ZVBLVXPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.63
• 重原子数：
  35.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  151.93
• 氢给体数：
  4.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 锂硼氢 、 戴斯-马丁氧化剂 作用下， 生成
  参考文献：
  名称：

  Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease

  摘要：

  The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The inhibitory activity of the compounds with the protease and with a norovirus cell-based replicon system was investigated. Members of this class of compounds exhibited noteworthy activity both in vitro and in a cell-based replicon system. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.07.016
• 作为产物：
  描述：

  (2S)-2-((叔丁氧基羰基)氨基)-3-(2-氧代吡咯烷-3-基)丙酸甲酯 在 N-甲基吗啉 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease

  摘要：

  The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The inhibitory activity of the compounds with the protease and with a norovirus cell-based replicon system was investigated. Members of this class of compounds exhibited noteworthy activity both in vitro and in a cell-based replicon system. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.07.016