22-(2-Acetylsulfanylethylamino)-22-oxodocosa-10,12-diynoic acid | 351154-64-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 22-(2-Acetylsulfanylethylamino)-22-oxodocosa-10,12-diynoic acid
• 英文别名: 22-(2-acetylsulfanylethylamino)-22-oxodocosa-10,12-diynoic acid
• CAS: 351154-64-8
• 化学式: C₂₆H₄₁NO₄S
• 分子量: 463.682
• InChiKey: WJLXASMPJZMQEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  32
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  22-(2-Acetylsulfanylethylamino)-22-oxodocosa-10,12-diynoic acid 在 lithium hydroxide 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 为溶剂， 反应 22.0h， 生成
  参考文献：
  名称：

  Synthesis of Conjugated Diacetylene, Metal-Chelating Monomers for Polymerizable Monolayer Assemblies

  摘要：

  [GRAPHICS]Self-assembled monolayers (SAMs) of thiols on gold have been used for numerous applications. For protein targeting applications, one successful strategy is to use a metal chelating SAM. It has also been demonstrated that polymerized SAMs are much more stable than non polymerized counterparts. We report herein, the synthesis of several polymerizable, metal-chelating thiols capable of complexing luminescent lanthanide ions.

  DOI：

  10.1021/ol015931+
• 作为产物：
  描述：

  10,12-二十二碳二炔二酸 、 硫代乙酸S-(2-氨基-乙基)酯盐酸盐 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以71%的产率得到22-(2-Acetylsulfanylethylamino)-22-oxodocosa-10,12-diynoic acid
  参考文献：
  名称：

  Synthesis of Conjugated Diacetylene, Metal-Chelating Monomers for Polymerizable Monolayer Assemblies

  摘要：

  [GRAPHICS]Self-assembled monolayers (SAMs) of thiols on gold have been used for numerous applications. For protein targeting applications, one successful strategy is to use a metal chelating SAM. It has also been demonstrated that polymerized SAMs are much more stable than non polymerized counterparts. We report herein, the synthesis of several polymerizable, metal-chelating thiols capable of complexing luminescent lanthanide ions.

  DOI：

  10.1021/ol015931+

文献信息

• Synthesis of Conjugated Diacetylene, Metal-Chelating Monomers for Polymerizable Monolayer Assemblies
  作者：Bidhan C. Roy、Sanku Mallik

  DOI：10.1021/ol015931+

  日期：2001.6.1

  [GRAPHICS]Self-assembled monolayers (SAMs) of thiols on gold have been used for numerous applications. For protein targeting applications, one successful strategy is to use a metal chelating SAM. It has also been demonstrated that polymerized SAMs are much more stable than non polymerized counterparts. We report herein, the synthesis of several polymerizable, metal-chelating thiols capable of complexing luminescent lanthanide ions.