4-(4-Bromophenyl)-2,6-bis(6-bromopyridin-2-yl)pyridine | 929207-09-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(4-Bromophenyl)-2,6-bis(6-bromopyridin-2-yl)pyridine
• CAS: 929207-09-0
• 化学式: C₂₁H₁₂Br₃N₃
• 分子量: 546.058
• InChiKey: RVOXBRFGTDIXKK-UHFFFAOYSA-N

物化性质

• 沸点：
  573.1±45.0 °C(Predicted)
• 密度：
  1.741±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-Bromophenyl)-2,6-bis(6-bromopyridin-2-yl)pyridine 在 bis-triphenylphosphine-palladium(II) chloride potassium carbonate 、 联硼酸频那醇酯 作用下， 以 1,4-二氧六环 、 甲醇 、 二甲基亚砜 为溶剂， 反应 48.0h， 生成 4-[4-[4-[2,6-Bis(6-methoxypyridin-2-yl)pyridin-4-yl]phenyl]phenyl]-2,6-bis(6-methoxypyridin-2-yl)pyridine
  参考文献：
  名称：

  Diverse Synthesis of Novel Bisterpyridines via Suzuki-Type Cross-Coupling

  摘要：

  A new protocol is presented for the synthesis of novel bisterpyridine derivatives using palladium-catalyzed Miyaura- and Suzuki-type cross-couplings as the key reactions. This protocol is quick, efficient, mild, and broadly applicable for the construction of versatile bisterpyridines by symmetric and unsymmetric introduction of various substituents in the pyridine rings as well as by tuning the spacers for bridging the two terpyridine moieties.

  DOI：

  10.1021/ol062788h
• 作为产物：
  描述：

  2-乙酰基-6-溴吡啶 、 对溴苯甲醛 在 ammonium hydroxide 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 60.0h， 以72%的产率得到4-(4-Bromophenyl)-2,6-bis(6-bromopyridin-2-yl)pyridine
  参考文献：
  名称：

  Diverse Synthesis of Novel Bisterpyridines via Suzuki-Type Cross-Coupling

  摘要：

  A new protocol is presented for the synthesis of novel bisterpyridine derivatives using palladium-catalyzed Miyaura- and Suzuki-type cross-couplings as the key reactions. This protocol is quick, efficient, mild, and broadly applicable for the construction of versatile bisterpyridines by symmetric and unsymmetric introduction of various substituents in the pyridine rings as well as by tuning the spacers for bridging the two terpyridine moieties.

  DOI：

  10.1021/ol062788h