4-异氰酰基-3,5-二甲基-1-苯基-1H-吡唑 | 637335-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-异氰酰基-3,5-二甲基-1-苯基-1H-吡唑
• 英文名称: 4-Isocyanato-3,5-dimethyl-1-phenyl-1H-pyrazole
• 英文别名: 4-isocyanato-3,5-dimethyl-1-phenylpyrazole
• CAS: 637335-93-4
• 化学式: C₁₂H₁₁N₃O
• mdl: MFCD09055409
• 分子量: 213.23
• InChiKey: FDFNCUNVKIOCAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  47.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Amide substituted xanthine derivatives
  申请人：——

  公开号：US20040014766A1

  公开（公告）日：2004-01-22

  The present invention is a 1,3,8 substituted xanthine derivative of formula I 1 or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 and R 3 are as defined in the specification. Compounds of formula I and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

  本发明是一种具有如下结构的1,3,8取代黄嘌呤衍生物（I1）或其药学上可接受的盐，其中R1、R2和R3如规范中定义。公式I的化合物及其药学上可接受的盐或前药显示出作为糖异生调节剂的活性。
• [EN] AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY<br/>[FR] DERIVES DE XANTHINE A SUBSTITUTION AMIDE A ACTIVITE DE MODULATION DE LA GLUCONEOGENESE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003106459A1

  公开（公告）日：2003-12-24

  The present invention is a 1,3,8 substituted xanthine derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

  本发明是一种式（I）的1,3,8取代黄嘌呤衍生物或其药用盐，其中R1、R2和R3如规范中所定义。式（I）化合物及其药用盐或前药显示为糖异生调节剂的活性。
• AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1515972A1

  公开（公告）日：2005-03-23
• THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：GRIFFIOEN Gerard

  公开号：US20090054410A1

  公开（公告）日：2009-02-26

  This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides various methods for producing such substituted 1,2,4-thiadiazole derivatives.
• US7135475B2
  申请人：——

  公开号：US7135475B2

  公开（公告）日：2006-11-14