| 1201697-61-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• CAS: 1201697-61-1
• 化学式: C₁₄H₁₂O₄
• 分子量: 244.247
• InChiKey: PWNDOEWRDYAHOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.76
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 乙腈 为溶剂， 以30%的产率得到
  参考文献：
  名称：

  Sodium borohydride or potassium carbonate-mediated intramolecular Michael addition: a general method for the synthesis of fused dihydrofuran and furan derivatives

  摘要：

  A simple and convenient method for the synthesis of fused dihydrofuran derivatives using NaBH4-mediated reductive cyclization and fused furan derivatives by K2CO3-mediated intramolecular Michael addition followed by acid-catalyzed methanol elimination has been developed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.071
• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 4-bromo-2H-chromene-3-carbaldehyde 在 四丁基溴化铵 、 sodium carbonate 、 palladium dichloride 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Sodium borohydride or potassium carbonate-mediated intramolecular Michael addition: a general method for the synthesis of fused dihydrofuran and furan derivatives

  摘要：

  A simple and convenient method for the synthesis of fused dihydrofuran derivatives using NaBH4-mediated reductive cyclization and fused furan derivatives by K2CO3-mediated intramolecular Michael addition followed by acid-catalyzed methanol elimination has been developed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.071

文献信息

• An efficient synthesis of pyrrole and fluorescent isoquinoline derivatives using NaN3/NH4Cl promoted intramolecular aza-annulation
  作者：Akash Jana、Susanta Kumar Manna、Suresh Kumar Mondal、Arabinda Mandal、Saikat Kumar Manna、Avijit Jana、Bidyut Kumar Senapati、Manas Jana、Shubhankar Samanta

  DOI：10.1016/j.tetlet.2016.07.002

  日期：2016.8

  An efficient synthetic protocol of pyrroles and isoquinolines through NaN3/NH4Cl promoted intramolecular aza-annulation of formyl group with suitable alkenes or alkynes is described in high yield and regioselectivities. The metal free exo-trig and endo-dig aza-cyclisation has been extended for the synthesis of bicyclic or tricyclic pyrroles along with environment sensitive fluorescent isoquinoline

  以高收率和区域选择性描述了通过NaN 3 / NH 4 Cl促进的甲酰基分子内氮杂环化与合适的烯烃或炔烃的吡咯和异喹啉的有效合成方案。无金属外型- trig的和内切-挖氮杂环化已扩展为二环或三环的吡咯与环境敏感的荧光异喹啉衍生物沿合成。反应发生的产率高，范围广且对官能团的耐受性高。lamellarin Q核心结构的简短合成证明了该方法的合成效用。
• Intramolecular macrolactonization, photophysical and biological studies of new class of polycyclic pyrrole derivatives
  作者：Suresh Kumar Mondal、Arabinda Mandal、Susanta Kumar Manna、Sk Asraf Ali、Maidul Hossain、Vangala Venugopal、Avijit Jana、Shubhankar Samanta

  DOI：10.1039/c7ob00160f

  日期：——

  N-substituted pyrrole derivatives and their application to construct macrocyclic oxazocinone via a two-component coupling reaction followed by base mediated intramolecular cyclization. This methodology provides an easy two-step approach to constitute a library of fused pyrrolo-oxazocinone derivatives in good yields under mild reaction conditions. The present methodology offers an easy access to the synthesis

  在本文中，我们报道了N-取代的吡咯衍生物的有效合成及其在通过两组分偶联反应，然后通过碱介导的分子内环化反应来构建大环恶唑烷酮中的应用。该方法提供了一种简单的两步法，可以在温和的反应条件下以高收率构建稠合的吡咯并恶唑啉酮衍生物库。本方法提供了容易获得荧光吡咯衍生物文库的合成的途径。其中，叔丁基2-（2-（3-羟丙基）-7-甲氧基-4,5-二氢- 2 H ^ -苯并[ ë] isoindol-1-yl）acetate已用于生物分析成像，显示有效的细胞内化作用，没有明显的细胞毒性。
• Dhara, Shubhendu; Gorai, Tumpa; Ahmed, Atiur, Journal of the Indian Chemical Society, 2013, vol. 90, # 10, p. 1675 - 1679
  作者：Dhara, Shubhendu、Gorai, Tumpa、Ahmed, Atiur、Ray, Jayanta K.

  DOI：——

  日期：——