2-十五烷基十七烷酸 | 103329-02-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-十五烷基十七烷酸
• 英文名称: 2-pentadecylheptadecanoic acid
• 英文别名: 2-pentadecyl-heptadecanoic acid；2-Pentadecyl-heptadecansaeure；2-pentadecyl heptadecanoic acid
• CAS: 103329-02-8
• 化学式: C₃₂H₆₄O₂
• 分子量: 480.859
• InChiKey: QFMKCPZRHLOIGP-UHFFFAOYSA-N

物化性质

• 沸点：
  580.1±18.0 °C(Predicted)
• 密度：
  0.871±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  15.1
• 重原子数：
  34
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-十五烷基十七烷酸 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 2-pentadecyl-heptadecan-1-ol
  参考文献：
  名称：

  Ulusoy, Istanbul Universitesi Fen Fakultesi Mecmuasi, Seri C: [Astronomi-Fizik-Kimya], 1954, vol. 19, p. 169

  摘要：

  DOI：
• 作为产物：
  描述：

  1-iodopentadecane 、 十七烷酸 在 sodium hydride 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 6.5h， 以29%的产率得到2-十五烷基十七烷酸
  参考文献：
  名称：

  Development of Vizantin, a Safe Immunostimulant, Based on the Structure–Activity Relationship of Trehalose-6,6′-dicorynomycolate

  摘要：

  Vizantin, 6,6'-bis-O-(3-nonyldodecanoy1)-alpha,alpha'-trehalose, was developed as a safe immunostimulator on the basis of a structure-activity relationship (SAR) study with trehalose 6,6'-dicorynomycolate (TDCM). It was possible to synthesize vizantin on a large scale more easily than in the case of TDCM, and the compound exhibited more potent prophylactic effect on experimental lung metastasis of B16-F0 melanoma cells. Because vizantin stimulated human macrophages, it is a promising candidate for clinical application.

  DOI：

  10.1021/jm3016443

文献信息

• Oil based blends of interpolymers of ethylene/alpha-olefins
  申请人：Soediono Mahalia

  公开号：US20070112127A1

  公开（公告）日：2007-05-17

  Polymer blends comprise at least one ethylene/α-olefin interpolymer and one or more oil. The oil can be an aromatic oil, napththenic oil, paraffinic oil or a combination thereof. The ethylene/α-olefin interpolymers are random block copolymers comprising at least a hard block and at least a soft block. The resulting blends can be used to make flexible molded articles.

  聚合物混合物至少包含一种乙烯/α-烯烃共聚物和一种或多种油。该油可以是芳香油、萘烷油、石蜡油或其组合。乙烯/α-烯烃共聚物是随机嵌段共聚物，包括至少一个硬块和至少一个软块。由此得到的混合物可用于制造柔性模塑制品。
• TREHALOSE COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL PRODUCT CONTAINING THE COMPOUND
  申请人：Nishizawa Mugio

  公开号：US20110218171A1

  公开（公告）日：2011-09-08

  A trehalose compound having high immunopotentiating activity and low toxicity is represented by formula (1). (In the formula, X and X′ each represents a phenyl, a naphthyl, R 1 —CHR 1 — (wherein R 1 and R 2 each represents a C 7 -C 21 alkyl group or the like) or the like; and n and n′ each independently represents an integer of 0-3). The compound exhibits a high activating effect on macrophages and neutrophils.

  具有高免疫增强活性和低毒性的海藻糖化合物由公式（1）表示。（在公式中，X和X'分别表示苯基，萘基，R1-CHR1-（其中R1和R2各代表C7-C21烷基或类似物），n和n'各自独立地表示0-3的整数）。该化合物对巨噬细胞和中性粒细胞具有高激活作用。
• FUCOSE DERIVATIVES, DRUGS CONTAINING THE SAME AS ACTIVE INGREDIENT, AND INTERMEDIATES FOR PRODUCING THE SAME
  申请人：KANEBO, LTD.

  公开号：EP0859005A1

  公开（公告）日：1998-08-19

  A compound of the formula (I): wherein X1 is a group of one of the following formulae (1), (2) and (3): R1 is a branched long chain alkyl group, R2 is ―CONHR3, a carboxyl group or a hydrogen atom, n is an integer of 0, 1 or 2, and R3 is a lower alkyl group or a phenyl group, or a pharmaceutically acceptable salt thereof, which is useful as a selectin inhibitor, and can be used in the prophylaxis or treatment of various inflammatory diseases such as inflammatory dermatitis (e.g., atopic dermatitis, contact hypersensitivity, photodermatosis, etc.), autoimmune chronic diseases (e.g. rheumatoid arthritis, chronic thyroiditis, etc.), and ischemia-reperfusion injury.

  式 (I) 的化合物： 其中 X1 是下式（1）、（2）和（3）之一的基团： R1是支链长链烷基，R2是-CONHR3、羧基或氢原子，n是0、1或2的整数，R3是低级烷基或苯基，或其药学上可接受的盐，可作为选择素抑制剂，用于预防或治疗各种炎症性疾病，如炎症性皮炎（如、特应性皮炎、接触性过敏、光敏性皮肤病等）、自身免疫性慢性疾病（如类风湿性关节炎、慢性甲状腺炎等）以及缺血再灌注损伤。
• Trehalose compound, method for producing same, and pharmaceutical product containing the compound
  申请人：Otsuka Chemical Co., Ltd.

  公开号：EP2567963A1

  公开（公告）日：2013-03-13

  It is an object of the present invention to provide a trehalose compound having high immunopotentiating activity and low toxicity. The compound exhibits a high activating effect on macrophages and neutrophils. The trehalose compound is represented by formula (1), wherein X represents R1-CHR2-, and X' represents R1'-CHR2'-, wherein R1, R1', R2 and R2' independently represent a C1-C21 alkyl group or a hydrogen atom, and wherein n and n' independently represent an integer of 0 to 3.

  本发明的目的是提供一种具有高免疫增强活性和低毒性的三卤糖化合物。该化合物对巨噬细胞和中性粒细胞具有很高的激活作用。 该曲卤糖化合物由式（1）表示，其中 X 代表 R1-CHR2-，X'代表 R1'-CHR2'-，其中 R1、R1'、R2 和 R2'独立地代表 C1-C21 烷基或氢原子，n 和 n'独立地代表 0 至 3 的整数。
• Anti-blocking compositions comprising interpolymers of ethylene/alpha-olefins
  申请人：Hoenig M. Stephen

  公开号：US20060199884A1

  公开（公告）日：2006-09-07

  Anti-blocking polymer compositions comprise at least one ethylene/α-olefin interpolymer and at least one anti-blocking agent comprising an amide. The ethylene/α-olefin interpolymers are a multi-block copolymer comprising at least one soft block and at least one hard block. The anti-blocking agent can be erucamide or other amides. The anti-blocking polymer composition has a pellet blocking strength of equal to or less than 100 lbs/ft 2 (4800 Pa). When the anti-blocking polymer composition is made into a film, the film has a blocking force of less than about 100 grams, measured according to ASTM method D-3354.

  抗阻塞聚合物组合物包括至少一种乙烯/α-烯烃互聚物和至少一种由酰胺组成的抗阻塞剂。乙烯/α-烯烃互聚物是一种多嵌段共聚物，由至少一个软嵌段和至少一个硬嵌段组成。抗阻塞剂可以是芥子酰胺或其他酰胺。抗阻塞聚合物组合物的颗粒阻塞强度等于或小于 100 磅/英尺 2 (4800 帕）。当抗阻塞聚合物组合物制成薄膜时，根据 ASTM 方法 D-3354 测量，薄膜的阻塞力小于约 100 克。