5-carboxymethoxy-isophthalic acid dimethyl ester | 108724-84-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-carboxymethoxy-isophthalic acid dimethyl ester
• 英文别名: 5-Carboxymethoxy-isophthalsaeure-dimethylester；1,3-Benzenedicarboxylic acid, 5(carboxymethoxy)-,1,3-dimethyl ester；2-[3,5-bis(methoxycarbonyl)phenoxy]acetic acid
• CAS: 108724-84-1
• 化学式: C₁₂H₁₂O₇
• 分子量: 268.223
• InChiKey: BSTZOEXIXQXOKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  99.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-carboxymethoxy-isophthalic acid dimethyl ester 、 3-(4-amino-phenyl)-3-oxo-propionic acid-[2-(2,4-di-tert-pentyl-phenoxy)-anilide] 在 氯化亚砜 作用下， 生成 3-{4-[2-(3,5-bis-methoxycarbonyl-phenoxy)-acetylamino]-phenyl}-3-oxo-propionic acid-[2-(2,4-di-tert-pentyl-phenoxy)-anilide]
  参考文献：
  名称：

  Compounds containing an isophthalate group useful in photography

  摘要：

  公开号：

  US02721798A1
• 作为产物：
  描述：

  甲醇 、 5-羟基间苯二甲酸二甲酯 、 溴乙酸 在 sodium methylate 作用下， 生成 5-carboxymethoxy-isophthalic acid dimethyl ester
  参考文献：
  名称：

  Mordanting basic dyes in photography

  摘要：

  公开号：

  US02756149A1

文献信息

• [EN] PHENYL CARBOXAMIDE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] COMPOSÉS DE PHÉNYL CARBOXAMIDE UTILISABLES COMME INHIBITEURS DE BÊTA SÉCRÉTASE DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2005113484A1

  公开（公告）日：2005-12-01

  The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及苯基羧酰胺化合物，这些化合物是β-分泌酶酶的抑制剂，并且在治疗β-分泌酶酶参与的疾病，如阿尔茨海默病中有用。该发明还涉及包含这些化合物的药物组合物以及在治疗β-分泌酶酶参与的这类疾病中使用这些化合物和组合物。
• Phenyl Carboxamide Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
  申请人：Coburn A. Craig

  公开号：US20070254958A1

  公开（公告）日：2007-11-01

  The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
• US7449599B2
  申请人：——

  公开号：US7449599B2

  公开（公告）日：2008-11-11
• [EN] PROCESS FOR MODIFYING AN AROMATIC POLYETHER BACKBONE AND A MODIFIED POLYETHER OBTAINED BY THIS PROCESS<br/>[FR] PROCÉDÉ DE MODIFICATION D'UN SQUELETTE POLYÉTHER AROMATIQUE ET UN POLYÉTHER MODIFIÉ OBTENU PAR CE PROCÉDÉ
  申请人：[en]TECHNISCHE UNIVERSITÄT BERLIN

  公开号：WO2022167637A1

  公开（公告）日：2022-08-11

  The present invention relates to a process for modifying an aromatic polyether backbone for obtaining a modified polyether comprising the steps of: a) providing the at least one aromatic polyether to be modified in dissolved state in an inert organic solvent, b) adding at least one modification reagent, c) adding at least one catalyst, d) carrying out the process until a desired degree of functionalization of said aromatic polyether backbone is reached, e) recovery of the modified aromatic polyether. The present invention also relates to a modified polyether obtained by this process.
• Mordanting basic dyes in photography
  申请人：EASTMAN KODAK CO

  公开号：US02756149A1

  公开（公告）日：1956-07-24