Benzo[1,3]dioxol-5-ylmethyl-benzyl-(3-butyl-2-phenyl-4,5,6,7-tetrahydro-3H-benzoimidazol-4-yl)-amine | 439567-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Benzo[1,3]dioxol-5-ylmethyl-benzyl-(3-butyl-2-phenyl-4,5,6,7-tetrahydro-3H-benzoimidazol-4-yl)-amine
• 英文别名: N-(1,3-benzodioxol-5-ylmethyl)-N-benzyl-3-butyl-2-phenyl-4,5,6,7-tetrahydrobenzimidazol-4-amine
• CAS: 439567-58-5
• 化学式: C₃₂H₃₅N₃O₂
• 分子量: 493.649
• InChiKey: ATALCKZADURJPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  39.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• High affinity small molecule C5a receptor modulators
  申请人：Thurkauf Andrew

  公开号：US20070027158A1

  公开（公告）日：2007-02-01

  This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors. Preferred compounds of the invention possess some or all of the following properties in that they are: 1) multi-aryl in structure, 2) heteroaryl in structure, 3) a pharmaceutically acceptable oral dose can provide a detectable in vitro effect, 4) comprise fewer than four or preferably no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar or sub-nanomolar concentrations. This invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds in treating a variety of inflammatory and immune system disorders. Additionally, this invention relates to the use such compounds as probes for the localization of C5a receptors.

  本发明涉及低分子量、非肽、非肽类似物有机分子，其作为哺乳动物补体C5a受体的调节剂。其中，优选的化合物是作为高亲和力C5a受体配体的，也是作为补体C5a受体的拮抗剂或反向激动剂的。该发明的优选化合物具有以下一些或全部特性：1）多芳基结构，2）杂芳基结构，3）药学上可接受的口服剂量可提供可检测的体外效果，4）包含少于四个或优选不含酰胺键，5）能够在纳摩尔或亚纳摩尔浓度下抑制白细胞趋化。此外，本发明还涉及包括这些化合物的制药组合物，以及将这些化合物用于治疗各种炎症和免疫系统疾病的用途。此外，本发明还涉及将这些化合物用作C5a受体定位的探针的用途。
• RESIN FILM AND METHOD FOR PRODUCTION THEREOF AND RESIN LAMINATED METAL PLATE USING THE RESIN FILM AND METHOD FOR MANUFACTURE THEREOF
  申请人：JFE Steel Corporation

  公开号：EP1449884A1

  公开（公告）日：2004-08-25

  The present invention relates to a resin film which consists of thermoplastic polyester resin containing 3 to 30% by weight of a granular resin with a grain diameter of 0.1 to 5 µm in weight fraction in entire resin, the granular resin being modified polyolefin resin containing 2 to 20% by weight of a functional group derived from carboxylic acid in terns of carboxylic acid, a manufacturing method for the resin film, a resin laminated metal sheet using the resin film, and a manufacturing method for the resin laminated metal sheet. By using the resin film in accordance with the present invention, a resin laminated metal sheet having high formability, impact resistance, adhesion, flavor property, and retort resistance can be obtained.

  本发明涉及一种由热塑性聚酯树脂构成的树脂薄膜，该树脂薄膜含有 3 至 30% （按重量计）在整个树脂中颗粒直径为 0.1 至 5 微米（按重量计）的颗粒树脂，该颗粒树脂是改性聚烯烃树脂，含有 2 至 20% （按重量计）从羧酸衍生的官能团（以羧酸为单位）；还涉及树脂薄膜的制造方法、使用该树脂薄膜的树脂层压金属板以及树脂层压金属板的制造方法。通过使用符合本发明的树脂薄膜，可以获得具有高成型性、抗冲击性、粘合性、风味特性和耐蒸煮性的树脂层压金属板。
• Resin film and manufacturing method for the same, and resin laminated metal sheet using said resin film and manufacturing method for the same
  申请人：Yoshida Yasuhide

  公开号：US20050191483A1

  公开（公告）日：2005-09-01

  [Problem] The object is to provide a resin film for metal sheet laminate which endures severe forming owing to excellent formability and impact resistance, and also to excellent adhesion after forming and heating, further gives stable performance independent of forming conditions, and also provides a laminated metal sheet, and a method for manufacturing the same. [Means for Resolution] The resin film for metal sheet laminate has a mixed resin in which a granular resin mainly existing in a state of grains having 0.1 to 5 μm in diameter is dispersed in a polyester resin having a main basic skeleton of polyethylene terephthalate and/or isophthalic acid copolymerized polyethylene terephthalate, in a range from 3 to 30% by weight in entire resin. The granular resin is a modified polyolefin resin containing a functional group derived from carboxylic acid in a range from 2 to 20% by weight as carboxylic acid.

  [问题]目的是提供一种金属板层压用树脂膜，该膜具有优异的成形性和耐冲击性，在成形和加热后具有优异的附着性，能够经受严酷的成形，而且不受成形条件的影响，性能稳定，同时还提供一种层压金属板及其制造方法。 [解决方法]金属板层压板用树脂膜具有一种混合树脂，其中主要以直径为 0.1 至 5 μm 的颗粒状态存在的颗粒状树脂分散在以聚对苯二甲酸乙二醇酯和/或间苯二甲酸共聚聚对苯二甲酸乙二醇酯为主要基本骨架的聚酯树脂中，占整个树脂重量的 3 至 30%。粒状树脂是一种改性聚烯烃树脂，含有羧酸衍生的官能团，其羧酸含量为 2%至 20%（按重量计）。
• US7063889B2
  申请人：——

  公开号：US7063889B2

  公开（公告）日：2006-06-20
• US7273653B2
  申请人：——

  公开号：US7273653B2

  公开（公告）日：2007-09-25