4-氟-2,3-二甲基苯甲醛 | 363134-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氟-2,3-二甲基苯甲醛
• 英文名称: 4-Fluoro-2,3-dimethylbenzaldehyde
• CAS: 363134-37-6
• 化学式: C₉H₉FO
• mdl: MFCD16295095
• 分子量: 152.16
• InChiKey: HAOCRTBODSLMGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三氯化铝 、 邻二氯苯 、 3-氟邻二甲苯 、 、 4-氟-2,3-二甲基苯甲醛 在 盐酸 一氧化碳 、 ice water 、 环己烷 、 水 、 magnesium sulfate 、 3-氟邻二甲苯 、 邻二氯苯 、 苯甲醛 作用下， 以 Parr®-brand 4522 为溶剂， 50.0 ℃ 、91.92 MPa 条件下， 反应 28.0h， 生成 2-fluoro-3,4-dimethylbenzaldehyde
  参考文献：
  名称：

  Method of producing fluorinated and chlorinated benzaldehydes and compositions thereof

  摘要：

  本发明涉及一种制备含氟芳香醛的方法，更具体地说，涉及一种在相对较低的压力、低温度和至多催化量的酸（例如水盐酸）存在下，通过氟化苯与一氧化碳和氯化铝反应的甲酰化过程。所得的氟化苯甲醛可用作形成多种不同化合物的前体，例如染料、调味料、香料、除草剂化合物、成核剂、聚合物添加剂等。该创新方法提供了一种非常经济、安全的方法，以非常高的产率生产这种氟化苯甲醛。

  公开号：

  US06300525B1

文献信息

• Novel fluorinated and alkylated alditol derivatives and compositions and polyolefin articles containing same
  申请人：——

  公开号：US20020062034A1

  公开（公告）日：2002-05-23

  Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain alkyl (or alkoxy) substituted fluorobenzylidene sorbitol acetals and polymer compositions thereof which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive fluorinated and alkylated benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.

  本发明提供了一种作为成核剂有用的塑料添加剂，特别是用于改善聚合材料的光学性能。更具体地说，本发明涉及某些烷基（或烷氧基）取代的氟苯基丙烯醇山梨醇缩醛及其聚合物组成物，可以用于食品或化妆品容器和包装等领域。这些创新的氟化和烷基化苯基丙烯醇山梨醇缩醛也可用作水和有机溶剂的凝胶剂，特别是用于制备止汗凝胶棒的溶剂。
• Method of producing fluorinated and chlorinated benzaldehydes and compositions thereof
  申请人：Milliken & Company

  公开号：US06300525B1

  公开（公告）日：2001-10-09

  A process for the preparation of aromatic aldehydes containing fluorine, and more particularly, to a formylation process for fluorinated aromatic derivatives through the reaction of fluorinated benzenes with carbon monoxide and aluminum chloride at a relatively low pressure, a low temperature, and in the presence of at most a catalytic amount of an acid (such as aqueous hydrochloric acid) is herein disclosed. The resultant fluorinated benzaldehydes are useful as precursors to the formation of a number of different compounds, such as dyestuffs, flavorings, fragrances, herbicidal compounds, nucleating agents, polymer additives, and the like. The inventive method provides a very cost effective and safe procedure for producing such fluorinated benzaldehydes in very high yields.

  本发明涉及一种制备含氟芳香醛的方法，更具体地说，涉及一种在相对较低的压力、低温度和至多催化量的酸（例如水盐酸）存在下，通过氟化苯与一氧化碳和氯化铝反应的甲酰化过程。所得的氟化苯甲醛可用作形成多种不同化合物的前体，例如染料、调味料、香料、除草剂化合物、成核剂、聚合物添加剂等。该创新方法提供了一种非常经济、安全的方法，以非常高的产率生产这种氟化苯甲醛。
• SULFONAMIDE COMPOUND OR SALT THEREOF
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3466934A1

  公开（公告）日：2019-04-10

  The present invention provides a novel sulfonamide compound having a ribonucleotide reductase inhibitory activity or a salt thereof, and a pharmaceutical composition containing the same as an active ingredient. A compound represented by Formula (I) [wherein, X1 represents an oxygen atom or the like; X2 represents an oxygen atom; X3 represents -NH-; X4 represents a hydrogen atom or the like; R1 represents -C(R11)(R12)- or the like; R11 and R12 are the same or different and each represents a hydrogen atom or the like; R2 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R3 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R4 represents a hydrogen atom or the like] or a salt thereof.

  本发明提供了一种具有核糖核苷酸还原酶抑制活性的新型磺酰胺化合物或其盐，以及含有该化合物作为活性成分的药物组合物。 由式(I)代表的化合物[其中，X1代表氧原子或类似物；X2代表氧原子；X3代表-NH-；X4代表氢原子或类似物；R1代表-C(R11)(R12)-或类似物；R11和R12相同或不同且各自代表氢原子或类似物；R2代表任选取代的C6-C14芳烃基团或类似物；R3代表任选取代的C6-C14芳烃基团或类似物；R4代表氢原子或类似物]或其盐。
• ANTITUMOR AGENT
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3718545A1

  公开（公告）日：2020-10-07

  The present invention provides a method of enhancing an antitumor effect by a compound strongly inhibiting ribonucleotide reductase (RNR) or a salt thereof. A combination formulation involving combined administration of a sulfonamide compound represented by Formula (I) [In the formula, X1 represents an oxygen atom or the like; X2 represents an oxygen atom; X3 represents -NH-; X4 represents a hydrogen atom or the like; R1 represents -C(R11) (R12)- or the like; R11 and R12 are the same or different and each represents a hydrogen atom or the like; R2 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R3 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R4 represents a hydrogen atom or the like] or a salt thereof, having RNR inhibitory activity, and other antitumor agent(s).

  本发明提供了一种通过强抑制核糖核苷酸还原酶（RNR）的化合物或其盐增强抗肿瘤效果的方法。 一种组合制剂涉及联合给药由式(I)代表的磺酰胺化合物[式中，X1代表氧原子或类似物；X2代表氧原子；X3代表-NH-；X4代表氢原子或类似物；R1代表-C(R11)(R12)-或类似物；R11和R12相同或不同，各自代表氢原子或类似物；R2代表任选取代的C6-C14芳烃基团或类似物；R3代表任选取代的C6-C14芳烃基团或类似物；R4代表氢原子或类似物]或其盐，具有RNR抑制活性，以及其他抗肿瘤剂。
• Sulfonamide compound or salt thereof
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：US10889555B2

  公开（公告）日：2021-01-12

  The present invention provides a novel sulfonamide compound having a ribonucleotide reductase inhibitory activity or a salt thereof, and a pharmaceutical composition containing the same as an active ingredient. A compound represented by Formula (I) [wherein, X1 represents an oxygen atom or the like; X2 represents an oxygen atom; X3 represents —NH—; X4 represents a hydrogen atom or the like; R1 represents —C(R11)(R12)— or the like; R11 and R12 are the same or different and each represents a hydrogen atom or the like; R2 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R3 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R4 represents a hydrogen atom or the like] or a salt thereof.

  本发明提供了一种具有核糖核苷酸还原酶抑制活性的新型磺酰胺化合物或其盐，以及含有该化合物作为活性成分的药物组合物。 由式(I)代表的化合物[其中，X1代表氧原子或类似物；X2代表氧原子；X3代表-NH-；X4代表氢原子或类似物；R1代表-C(R11)(R12)-或类似物；R11和R12相同或不同且各自代表氢原子或类似物；R2代表任选取代的C6-C14芳烃基团或类似物；R3代表任选取代的C6-C14芳烃基团或类似物；R4代表氢原子或类似物]或其盐。