3',4'-di-O-t-butyldimethylsilyl-5,6-dihydrouridine | 1248343-58-9

• 分子结构分类: 有机化合物
• 英文名称: 3',4'-di-O-t-butyldimethylsilyl-5,6-dihydrouridine
• CAS: 1248343-58-9
• 化学式: C₂₁H₄₂N₂O₆Si₂
• 分子量: 474.745
• InChiKey: LONLCZROMSRXRP-VDHUWJSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  31.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  97.33
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  香叶基溴 、 3',4'-di-O-t-butyldimethylsilyl-5,6-dihydrouridine 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.17h， 生成
  参考文献：
  名称：

  Anti-Influenza Virus Compound from Streptomyces sp. RI18

  摘要：

  Screening for anti-influenza virus activity in compounds isolated from Streptomyces sp RI18, which was isolated using the membrane filter method, uncovered a novel compound, JBIR-68 (1), which contains a unique skeleton. Its structure was established by extensive NMR and MS analyses. In addition, 1 was synthesized to confirm the configuration of its sugar moiety. Compound 1 inhibited influenza virus growth in plaque assays.

  DOI：

  10.1021/ol102007d
• 作为产物：
  描述：

  2',3'-bis-O-(tert-butyldimethylsilyl)uridine 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 反应 42.0h， 以98%的产率得到3',4'-di-O-t-butyldimethylsilyl-5,6-dihydrouridine
  参考文献：
  名称：

  Anti-Influenza Virus Compound from Streptomyces sp. RI18

  摘要：

  Screening for anti-influenza virus activity in compounds isolated from Streptomyces sp RI18, which was isolated using the membrane filter method, uncovered a novel compound, JBIR-68 (1), which contains a unique skeleton. Its structure was established by extensive NMR and MS analyses. In addition, 1 was synthesized to confirm the configuration of its sugar moiety. Compound 1 inhibited influenza virus growth in plaque assays.

  DOI：

  10.1021/ol102007d