methyl 2-[2-benzyloxy-3-bromophenyl]-2-(2-methoxy-5-methylphenyl)acetate | 415949-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-[2-benzyloxy-3-bromophenyl]-2-(2-methoxy-5-methylphenyl)acetate
• 英文别名: Methyl 2-(3-bromo-2-phenylmethoxyphenyl)-2-(2-methoxy-5-methylphenyl)acetate
• CAS: 415949-82-5
• 化学式: C₂₄H₂₃BrO₄
• 分子量: 455.348
• InChiKey: SIVDEGOQMPNGSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-[2-benzyloxy-3-bromophenyl]-2-(2-methoxy-5-methylphenyl)acetate 在 palladium dihydroxide 氢气 、 三氟乙酸 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 12.0h， 以59%的产率得到methyl 2-(2-hydroxyphenyl)-2-(2-methoxy-5-methylphenyl)acetate
  参考文献：
  名称：

  α-Arylation of 2-Arylacetates and Benzofuran-2-one with Tricarbonyl(fluoroarene)chromium Complexes

  摘要：

  In order to synthesise fragments of the natural product diazonamide A, alpha-arylation of 2-arylacetates 3 and benzofuran-2-one with the aid of the tricarbonyl(fluoroarene)chromium complex rac-2 was investigated. After decomplexation of the products rac-4 and rac-6, it was possible to obtain 2,2-diaryl-acetates rac-5 and the 3-arylbenzofuran-2-one rac-7.

  DOI：

  10.1002/1099-0690(20021)2002:2<369::aid-ejoc369>3.0.co;2-7
• 作为产物：
  描述：

  2-methoxy-5-methyldiazonium tetrafluoroborate 在 三氟化硼乙醚 、 六羰基铬 作用下， 以 四氢呋喃 、 二丁醚 为溶剂， 反应 73.33h， 生成 methyl 2-[2-benzyloxy-3-bromophenyl]-2-(2-methoxy-5-methylphenyl)acetate
  参考文献：
  名称：

  α-Arylation of 2-Arylacetates and Benzofuran-2-one with Tricarbonyl(fluoroarene)chromium Complexes

  摘要：

  In order to synthesise fragments of the natural product diazonamide A, alpha-arylation of 2-arylacetates 3 and benzofuran-2-one with the aid of the tricarbonyl(fluoroarene)chromium complex rac-2 was investigated. After decomplexation of the products rac-4 and rac-6, it was possible to obtain 2,2-diaryl-acetates rac-5 and the 3-arylbenzofuran-2-one rac-7.

  DOI：

  10.1002/1099-0690(20021)2002:2<369::aid-ejoc369>3.0.co;2-7

文献信息

• α-Arylation of 2-Arylacetates and Benzofuran-2-one with Tricarbonyl(fluoroarene)chromium Complexes
  作者：Daniela Schley、Alexander Radspieler、Guido Christoph、Jürgen Liebscher

  DOI：10.1002/1099-0690(20021)2002:2<369::aid-ejoc369>3.0.co;2-7

  日期：2002.1

  In order to synthesise fragments of the natural product diazonamide A, alpha-arylation of 2-arylacetates 3 and benzofuran-2-one with the aid of the tricarbonyl(fluoroarene)chromium complex rac-2 was investigated. After decomplexation of the products rac-4 and rac-6, it was possible to obtain 2,2-diaryl-acetates rac-5 and the 3-arylbenzofuran-2-one rac-7.