ethyl 14-hydroxytetradecanoate | 910631-01-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 14-hydroxytetradecanoate
• CAS: 910631-01-5
• 化学式: C₁₆H₃₂O₃
• 分子量: 272.428
• InChiKey: KGFDDOITTLGDCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 14-hydroxytetradecanoate 在 氢氧化钾 作用下， 以 甲醇 、 水 为溶剂， 以88%的产率得到14-羟基豆蔻酸
  参考文献：
  名称：

  基于非对映选择性共轭加成的（R）-（–）-muscone的不对称合成

  摘要：

  （R）-（-）-Muscone是通过立体选择性的方式合成的，方法是将非对映体选择性共轭加成至（R，R）-环己烷-1,2-二醇的环状α，β-不饱和酯，并伴随自发Dieckmann缩合。

  DOI：

  10.1039/c39910001438
• 作为产物：
  描述：

  十四烷二酸二甲酯 在 氢氧化钾 、 二甲基硫 、 硼烷 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 ethyl 14-hydroxytetradecanoate
  参考文献：
  名称：

  基于非对映选择性共轭加成的（R）-（–）-muscone的不对称合成

  摘要：

  （R）-（-）-Muscone是通过立体选择性的方式合成的，方法是将非对映体选择性共轭加成至（R，R）-环己烷-1,2-二醇的环状α，β-不饱和酯，并伴随自发Dieckmann缩合。

  DOI：

  10.1039/c39910001438

文献信息

• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Anti-fouling Paints and Coatings
  申请人：Reactive Surfaces LTD

  公开号：US20150191607A1

  公开（公告）日：2015-07-09

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peptide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文披露了聚合材料，例如涂层、塑料、层压材料、复合材料、弹性体、粘合剂或密封剂；表面处理，例如纺织品整理或蜡；填充剂，用于这种聚合材料或表面处理，包括酯酶（例如脂肪水解酶、硫酸酯水解酶、有机磷化合物降解酶）的酶，降解细胞壁和/或细胞膜成分的酶（例如溶菌酶、裂解转葡糖苷酶），生物杀菌或生物稳定肽，和/或肽酶。本文还披露了通过将酶并入能够通过脂肪水解酶、水解酶和/或脲酶的活性进行化学交联的材料中，改变材料性能（例如使用寿命、柔韧性或刚度）的方法。
• NOVEL PYRIDINECARBOXAMIDE DERIVATIVES
  申请人：Nisshin Flour Milling Co., Ltd.

  公开号：EP0885886A1

  公开（公告）日：1998-12-23

  Pyridinecarboxamide derivatives of the formula (wherein n represents an integer of 14 - 18, and R represents a hydrogen atom or a straight or branched C1-C4 alkyl group) or physiologically acceptable salts thereof. The compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed death of neuronal cells (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage of cerebrovascular disorders and then the compounds are useful as an agent for inhibiting cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, the compounds have no hypotensive action which is considered to be side-effect in treating the acute stage cerebrovascular disorders and hardly show a behavior suppressing action so that they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders. Moreover, the compounds show a cerebral protective activity (an anti-anoxic activity), an increasing activity of cerebral blood flow, and an inhibiting activity of lipid peroxidation and these activities may lead to the increased utility as a therapeutic agent for cerebrovascular disorders.

  式中的吡啶甲酰胺衍生物 (其中 n 代表 14 - 18 的整数，R 代表氢原子或直链或支链 C1-C4 烷基）或其生理上可接受的盐。 这些化合物对脑水肿，尤其是缺血性脑水肿有很好的抑制作用，对神经元细胞的延迟死亡也有很好的抑制作用（抑制神经元细胞中 Ca 的内流）。脑水肿是脑血管疾病，尤其是脑血管疾病急性期的一种病理状态，因此，这些化合物可作为抑制脑水肿的药物或脑血管疾病的治疗药物。此外，这些化合物在治疗急性期脑血管疾病时没有被认为是副作用的降压作用，也几乎没有行为抑制作用，因此是一种特别适用于急性期脑血管疾病的优良治疗剂。此外，这些化合物还显示出脑保护活性（抗缺氧活性）、增加脑血流量活性和抑制脂质过氧化活性，这些活性可能会增加其作为脑血管疾病治疗剂的效用。
• Stereochemistry of Sagittamide A:  Prediction and Confirmation
  作者：Hirofumi Seike、Indranath Ghosh、Yoshito Kishi

  DOI：10.1021/ol061582d

  日期：2006.8.1

  The C5-C10 relative stereochemistry of sagittamide A was predicted, with the use of the (3)J(H,H) profiles assembled from the spin-coupling constants reported in the literature. The predicted relative stereochemistry was then confirmed by a total synthesis of two relevant remote diastereomers. The absolute configuration of sagittamide A was established through a detailed H-1 NMR analysis of the two remote diastereomers, followed by doping experiments of them with the authentic natural product.
• PYRIDINECARBOXAMIDE DERIVATIVES
  申请人：NISSHIN SEIFUN GROUP INC.

  公开号：EP0885886B1

  公开（公告）日：2002-05-29