methyl 4-(4-methylphenyl)-2-(morpholino)oct-3-enoate | 1519954-08-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 4-(4-methylphenyl)-2-(morpholino)oct-3-enoate
• CAS: 1519954-08-5
• 化学式: C₂₀H₂₉NO₃
• 分子量: 331.455
• InChiKey: AYOIROAZNHZLBA-SDXDJHTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  24.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  38.77
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  C₁₈H₃₄B₂O₄ 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium phosphate monohydrate 作用下， 以 四氢呋喃 、 乙醚 、 水 为溶剂， 反应 18.0h， 生成 methyl 4-(4-methylphenyl)-2-(morpholino)oct-3-enoate
  参考文献：
  名称：

  Regio- and Stereocontrolled Access to γ-Boronated Unsaturated Amino Esters and Derivatives from (Z)-Alkenyl 1,2-Bis(boronates)

  摘要：

  The Borono-Mannich reaction of (Z)-1-alkene-1,2-diboronic esters proceeded regioselectively at the terminal C-B bond to afford (E)-gamma-boronated unsaturated amino esters in good yields. These compounds were then subjected to Suzuki couplings for the creation of diversely substituted olefinic amino acid systems. Several other functional transformations were also carried out to illustrate the synthetic utility of the Petasis products.

  DOI：

  10.1021/jo402237t

文献信息

• Synthesis of 1-Amino-<i>1H</i>-Indenes via a Sequential Suzuki–Miyaura Coupling/Petasis Condensation Sequence
  作者：Vankudoth Jayaram、Tailor Sridhar、Gangavaram V. M. Sharma、Fabienne Berrée、Bertrand Carboni

  DOI：10.1021/acs.joc.6b02549

  日期：2017.2.3

  An efficient and straightforward synthesis of 1-amino-1H-indenes is reported from 1,2-bis(boronates) via a sequential Suzuki–Miyaura coupling/Petasis cyclization reaction. Starting from the same monoboronic ester intermediates, an intermolecular version of this approach also afforded (Z)-α,β-unsaturated amino esters in moderate to good yields.

  据报道，通过顺序的Suzuki-Miyaura偶联/ Petasis环化反应，由1,2-双（硼酸酯）可以有效而直接地合成1-氨基-1H-茚。从相同的单硼酸酯中间体开始，这种方法的分子间形式还以中等至良好的产率提供了（Z）-α，β-不饱和氨基酯。