1-(2,4-dichlorophenyl)-4-ethyl-5-phenyl-1H-pyrazole-3-carboxylic acid | 1426436-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2,4-dichlorophenyl)-4-ethyl-5-phenyl-1H-pyrazole-3-carboxylic acid
• 英文别名: 1-(2,4-Dichlorophenyl)-4-ethyl-5-phenylpyrazole-3-carboxylic acid
• CAS: 1426436-68-1
• 化学式: C₁₈H₁₄Cl₂N₂O₂
• 分子量: 361.227
• InChiKey: LPLICDRCSXTHKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Ethyl-1-(2,4-dichlorophenyl)-5-phenylpyrazole-3-carboxylic acid ethyl ester 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以1.12 g的产率得到1-(2,4-dichlorophenyl)-4-ethyl-5-phenyl-1H-pyrazole-3-carboxylic acid
  参考文献：
  名称：

  “One-Pot” Synthesis of 4-Substituted 1,5-Diaryl-1H-pyrazole-3-carboxylic Acids via a MeONa/LiCl-Mediated Sterically Hindered Claisen Condensation–Knorr Reaction–Hydrolysis Sequence

  摘要：

  A "one-pot" synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylic acids was first reported in moderate to good yields. This concise procedure, featuring efficiency and green chemistry, was composed of MeONa/LiCl-mediated sterically hindered Claisen condensation, Knorr reaction and hydrolysis.

  DOI：

  10.1055/s-0032-1317668

文献信息

• TERNARY HERBICIDAL COMPOSITION AND APPLICATION THEREOF
  申请人：Qingdao KingAgroot Chemical Compound Co., Ltd.

  公开号：EP3818830A1

  公开（公告）日：2021-05-12

  The present invention belongs to the technical field of pesticides, and particularly relates to a ternary herbicidal composition and application thereof. The ternary herbicidal composition comprises an active ingredient A, an active ingredient B and an active ingredient C in an herbicidally effective amount, wherein the active ingredient A is huanbifucaotong and/or salt thereof; the active ingredient B is diflufenican and/or salt thereof; the active ingredient C is flufenacet and/or salt thereof. The composition is capable of effectively controlling weeds such as Malachium aquaticum, Matricaria recutita, Veronica didyma Tenore, Senecio scandens, Sonchus arvensis, etc. in a crop, and has the following advantages: exhibiting a broad spectrum of weed control, being used in a reduced dose, being safe for crops, and being capable of bringing about a synergistic effect and removing resistant weeds.

  本发明属于农药技术领域，尤其涉及一种三元除草组合物及其应用。该三元除草组合物包括除草有效量的有效成分A、有效成分B和有效成分C，其中有效成分A为黄芩苷和/或其盐；有效成分B为双氟磺草胺和/或其盐；有效成分C为氟苯乙酰胺和/或其盐。该组合物能有效防除作物中的杂草，如水生马蔺、荠菜、天南星、薹草、苣荬菜等，并具有以下优点：防除杂草谱广、使用剂量小、对作物安全、能产生增效作用并除去抗性杂草。
• HERBICIDAL COMPOSITION CONTAINING R-TYPE PYRIDYLOXY CARBOXYLIC ACID DERIVATIVE AND USE THEREOF
  申请人：Qingdao KingAgroot Chemical Compound Co., Ltd.

  公开号：EP4005384A1

  公开（公告）日：2022-06-01

  The present invention belongs to the technical field of pesticides, and particularly relates to an herbicidal composition comprising R-pyridyloxycarboxylic acid and derivative and an application thereof. The composition comprises an active ingredient A and an active ingredient B in an herbicidally effective amount, wherein, the active ingredient A is one or more compounds selected from an R-pyridyloxycarboxylic acid represented by formula I and salt, ester derivative thereof, wherein, R1, R2each independently represent halogen, C1-C6 alkyl, halo C1-C6 alkyl or C3-C6 cycloalkyl; R3 represents hydrogen, halogen, C1-C6 alkyl or halo C1-C6 alkyl; Q represents C1-C6 alkyl, etc.; Y represents amino, etc.; the active ingredient B is selected from the following one or more compounds or acid or salt or ester derivatives thereof, ALS inhibitor, ACCase inhibitor, PSII inhibitor, HPPD inhibitor, PDS inhibitor, DOXP inhibitor, PPO inhibitor, Synthetic hormone, EPSPS inhibitor, GS inhibitor, PSI inhibitor. The composition is capable of effectively controlling various weeds, and has the following advantages: exhibiting a broad spectrum of weed control, being used in a reduced dose, and being capable of bringing about a synergistic effect and removing resistant weeds.

  本发明属于农药技术领域，尤其涉及一种由 R-吡啶氧羧酸及其衍生物组成的除草组合物及其应用。该组合物包括除草有效量的活性成分 A 和活性成分 B，其中，活性成分 A 是一种或多种选自式 I 所代表的 R-吡啶氧羧酸及其盐、酯衍生物的化合物、 其中，R1、R2各自独立地代表卤素、C1-C6烷基、卤代C1-C6烷基或C3-C6环烷基； R3 代表氢、卤素、C1-C6 烷基或卤代 C1-C6 烷基； Q 代表 C1-C6 烷基等； Y 代表氨基等； 活性成分 B 选自下列一种或多种化合物或其酸或盐或酯衍生物、ALS 抑制剂、ACCase 抑制剂、PSII 抑制剂、HPPD 抑制剂、PDS 抑制剂、DOXP 抑制剂、PPO 抑制剂、合成激素、EPSPS 抑制剂、GS 抑制剂、PSI 抑制剂。该组合物能有效防除各种杂草，并具有以下优点：防除杂草谱广、使用剂量小、能产生增效作用和清除抗性杂草。
• HERBIZIDE SUBSTITUIERTE N-TETRAZOLYLARYLCARBOXAMIDE
  申请人：Bayer Aktiengesellschaft

  公开号：EP3911633A1

  公开（公告）日：2021-11-24
• US7563749B2
  申请人：——

  公开号：US7563749B2

  公开（公告）日：2009-07-21
• [DE] HERBIZIDE SUBSTITUIERTE N-TETRAZOLYLARYLCARBOXAMIDE<br/>[EN] HERBICIDAL SUBSTITUTED N-TETRAZOLYL ARYL CARBOXAMIDES<br/>[FR] N-TÉTRAZOLYLARYLCARBOXAMIDES SUBSTITUÉS HERBICIDES
  申请人：BAYER AG

  公开号：WO2020148175A1

  公开（公告）日：2020-07-23

  Es werden Arylcarboxamide mit der allgemeinen Formel (I) als Herbizide beschrieben. In dieser Formel (I) stehen RX, X, Y und Z für Reste wie Alkyl und Halogen.