1,2-diethoxy-4-(2-nitro-cis-propenyl)-benzene | 131981-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,2-diethoxy-4-(2-nitro-cis-propenyl)-benzene
• 英文别名: 1,2-Diaethoxy-4-(2-nitro-cis-propenyl)-benzol；3.4-Diaethoxy-1-(2-nitro-propen-(1)-yl-(1c))-benzol；3.4-Diaethoxy-1-(2-nitro-cis-propenyl)-benzol；1,2-diethoxy-4-[(E)-2-nitroprop-1-enyl]benzene
• CAS: 131981-72-1
• 化学式: C₁₃H₁₇NO₄
• 分子量: 251.282
• InChiKey: JMPFGBSWLWZTIG-CSKARUKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  64.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2-diethoxy-4-(2-nitro-cis-propenyl)-benzene 在 chromium dichloride 作用下， 以 四氢呋喃 、 盐酸 为溶剂， 反应 4.0h， 以78%的产率得到(3,4-diethoxy-phenyl)-acetone
  参考文献：
  名称：

  氯化铬（II）还原α，β-不饱和硝基烯烃。羰基化合物的简便路线。

  摘要：

  α，β-不饱和硝基烯烃很容易被氯化铬（II）还原成相应的羰基化合物，收率很高。

  DOI：

  10.1016/s0040-4039(00)89248-5
• 作为产物：
  描述：

  1-acetoxy-1-(3,4-diethoxy-phenyl)-2-nitro-propane 在 氢氧化钾 作用下， 生成 1,2-diethoxy-4-(2-nitro-cis-propenyl)-benzene
  参考文献：
  名称：

  The price of peace: the personal and financial cost of paramilitary punishments in Northern Ireland

  摘要：

  The aim of this study was to compare the injuries sustained during paramilitary punishments both before and after the onset of "peace" in Northern Ireland. A retrospective chart review was performed looking at age, injuries, treatments instituted, theatre time, length of hospital stay and overall cost of care. In the 10-month period before the ceasefire, 31 patients were treated after sustaining paramilitary punishment shootings. Mean age was 25.2 years. All patients had small entrance and exit wounds with minimal soft tissue disruption. A total of 18 fractures were recorded in 15 patients and 14 arteries required repair. Mean operative time was 2.6 h, mean hospital stay 7.61 days and mean cost per patient pound 3102. In the following 10-month period 28 patients were admitted after punishments, only one of whom had been shot, all others had been beaten with sticks and clubs. Mean age was 27.4 years. In 52 limbs, 64 fractures were recorded and 44% of these were open; 15 of the fractures were Gustilo and Anderson Grade III or greater and 11 of the fractures were intra-articular. There were no arterial injuries. Mean operative time was 2.6 h, mean hospital stay 12.4 h and mean cost per patient pound 3849. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0020-1383(99)00197-7

文献信息

• Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150210682A1

  公开（公告）日：2015-07-30

  The invention provides novel compounds having the general formula: wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein, compositions including the compounds and methods of using the compounds.

  这项发明提供了具有一般公式的新化合物： 其中R1、R2、R3、R4、R5和R6如本文所述，包括这些化合物的组合物和使用这些化合物的方法。
• Papaverine Homologs. III. The Preparation of Some 3-Methylisoquinolines¹
  作者：Edwin R. Shepard、John F. Noth、Herschel D. Porter、Claudene K. Simmans

  DOI：10.1021/ja01138a051

  日期：1952.9
• Kabalka, George W.; Pace, R. David; Wadgaonkar, P.P., Synthetic Communications, 1990, vol. 20, # 16, p. 2453 - 2458
  作者：Kabalka, George W.、Pace, R. David、Wadgaonkar, P.P.

  DOI：——

  日期：——
• GOUDGAON, NAGANNA M.;WADGAONKAR, PRAKASH P.;KABALKA, GEORGE W., SYNTH. COMMUN., 19,(1989) N-6, C. 805-811
  作者：GOUDGAON, NAGANNA M.、WADGAONKAR, PRAKASH P.、KABALKA, GEORGE W.

  DOI：——

  日期：——
• KABALKA, GEORGE W.;PACE, R. DAVID;WADGAONKAR, P. P., SYNTH. COMMUN., 20,(1990) N6, C. 2453-2548
  作者：KABALKA, GEORGE W.、PACE, R. DAVID、WADGAONKAR, P. P.

  DOI：——

  日期：——