N-[(1H-pyrazol-4-yl)methyl]acetamide | 1184541-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[(1H-pyrazol-4-yl)methyl]acetamide
• 英文别名: N-(1H-pyrazol-4-ylmethyl)acetamide
• CAS: 1184541-34-1
• 化学式: C₆H₉N₃O
• 分子量: 139.16
• InChiKey: VFAFDDVJGKOBTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] TROPOMYOSIN-RELATED KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASES APPARENTÉES À LA TROPOMYOSINE
  申请人：PFIZER

  公开号：WO2015170218A1

  公开（公告）日：2015-11-12

  The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

  本发明涉及式I化合物及其药用可接受的盐，其中取代基如本文所述，并且在医学上的应用，特别是作为TrkA拮抗剂。
• TROPOMYOSIN-RELATED KINASE INHIBITORS
  申请人：PFIZER INC

  公开号：US20150322043A1

  公开（公告）日：2015-11-12

  The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

  本发明涉及公式I化合物及其药学上可接受的盐，其中取代基如本文所述，并且它们在医学上的应用，特别是作为TrkA拮抗剂。
• MIXED DISULFIDE CONJUGATES OF THIENOPYRIDINE COMPOUNDS AND USES THEREOF
  申请人：The Regents of The University of Michigan

  公开号：EP3288590B1

  公开（公告）日：2021-03-03
• Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety
  申请人：PFIZER INC.

  公开号：US20170197939A1

  公开（公告）日：2017-07-13

  The present invention relates to compounds of Formula I and their prodrugs and pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.
• US9328096B2
  申请人：——

  公开号：US9328096B2

  公开（公告）日：2016-05-03