N-vinylpyridinium chloride | 45590-51-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-vinylpyridinium chloride
• 英文别名: vinylpyridinium chloride；1-Ethenylpyridin-1-ium chloride；1-ethenylpyridin-1-ium;chloride
• CAS: 45590-51-0
• 化学式: C₇H₈N*Cl
• 分子量: 141.6
• InChiKey: XTPPAVHDUJMWEX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.92
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  三苯基膦 、 N-vinylpyridinium chloride 在 氢溴酸 、 苯甲醛 作用下， 以 水 、 乙腈 为溶剂， 反应 15.0h， 以22%的产率得到1,2-bis(triphenylphosphonio)ethane dichloride
  参考文献：
  名称：

  Features of the reaction of 2,3-dihalopropanoic acids with pyridines and nucleophilic addition to N-vinylpyridinium salts

  摘要：

  The example of vinylpyridinium salts to establish for the first time the possibility of nucleophilic addition to the vinyl group in quaternary ammonium salts, which provides evidence against the concept that such reactions involve d orbitals. The nucleophilic addition reaction was accomplished with triphenylphosphine and pyridine. In the latter case, the suggested reaction scheme was confirmed by the observation of the Wittig reaction under the action of carbon dioxide and the Stevens reaggangement involving the double bond of the pyridinium ring and migrating 2-phosphonioethyl group. Procedures for preparing the starting vinylpyridinium salts. Reaction schemes were siggested.

  DOI：

  10.1134/s107036320807030x
• 作为产物：
  描述：

  吡啶 、 2,3-二氯丙酸 以 乙腈 为溶剂， 反应 8.0h， 以95%的产率得到N-vinylpyridinium chloride
  参考文献：
  名称：

  Reaction of 2,3-Dihalopropionic Acids and Their Derivatives with P- and N-Nucleophiles

  摘要：

  3-(三苯基膦亚氯)丙烯酸和 2,3-二氯丙酸与三苯基膦反应生成 1,2-双(三苯基膦亚氯)乙烷。在类似条件下，2,3-二溴丙酸发生脱溴反应，然后加入三苯基膦，经水处理后生成 3-（三苯基膦溴化）丙酸。2,3-二卤代丙腈发生类似反应，生成 3-（三苯基膦卤代）丙腈。2,3-二溴丙酰胺与三苯基膦的反应表明，E-(三苯基膦溴)丙烯酸能够与三苯基膦发生反应，这与之前的报道不同。吡啶与 2,3-二氢丙酸形成乙烯基吡啶鎓卤化物，而与脂肪族胺反应则产生脱氢卤化产物。

  DOI：

  10.1007/s11176-006-0009-z

文献信息

• Cosmetic composition
  申请人：UNILEVER PLC

  公开号：EP0415598A1

  公开（公告）日：1991-03-06

  A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from N-acylated amino-acids, in which the acyl group has from 2 to 20 carbon atoms, together with a cosmetically acceptable vehicle for the hair growth promoter.

  适用于哺乳动物皮肤和头发的局部应用的组合物，用于诱导、维持或增加头发生长，包括选择自N-酰化氨基酸的头发生长促进剂，其中酰基含有2至20个碳原子，以及用于头发生长促进剂的化妆品可接受载体。
• Carriers, Formulations, Methods For Formulating Unstable Active Agents For External Application And Uses Thereof
  申请人：Foamix Ltd.

  公开号：US20130189191A1

  公开（公告）日：2013-07-25

  The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.

  本公开教授了一种独特的四环素类抗生素外用给药配方，其中四环素类抗生素保持稳定。
• CARRIERS, FORMULATIONS, METHODS FOR FORMULATING UNSTABLE ACTIVE AGENTS FOR EXTERNAL APPLICATION AND USES THEREOF
  申请人：Tamarkin Dov

  公开号：US20100310476A1

  公开（公告）日：2010-12-09

  The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.

  本公开教授了独特的四环素类抗生素局部给药配方，其中四环素类抗生素保持稳定。
• DRUG-CONTAINING NANOPARTICLES
  申请人：Egashira Kensuke

  公开号：US20100331373A1

  公开（公告）日：2010-12-30

  The present invention relates to nanoparticles containing pioglitazone or a salt thereof and a biocompatible polymer, a pharmaceutical preparation containing the nanoparticles for the prophylaxis or treatment of arteriosclerotic diseases, and a stent carrying the nanoparticles. Using the nanoparticles of the present invention, rupture of arteriosclerotic plaque can be suppressed, and they are useful for the prophylaxis or treatment of arteriosclerotic diseases.

  本发明涉及含有吡格列酮或其盐和生物相容性聚合物的纳米颗粒，以及含有这些纳米颗粒的制药制剂，用于动脉硬化疾病的预防或治疗，以及携带这些纳米颗粒的支架。使用本发明的纳米颗粒可以抑制动脉硬化斑块的破裂，对于预防或治疗动脉硬化疾病非常有用。
• Treatment of keratinous fibres
  申请人：UNILEVER PLC

  公开号：EP0257807A2

  公开（公告）日：1988-03-02

  An aqueous single phase composition, particularly for use in the treatment of keratinous fibres, comprises a cationic polymer or mixtures thereof, an anionic monomer or mixtures thereof, and a solubilising agent chosen from amphoteric detergent active compounds, inorganic electrolytes and mixtures thereof. The composition should have an anionic to cationic charge ratio of from 0.2 to 1.0. When the monomer is an anionic dye, the composition can be employed in the dyeing of hair.

  一种水性单相组合物，特别是用于处理角质纤维的组合物，由阳离子聚合物或其混合物、阴离子单体或其混合物和增溶剂组成，增溶剂选自两性洗涤活性化合物、无机电解质及其混合物。 组合物的阴阳离子电荷比应在 0.2 至 1.0 之间。 当单体为阴离子染料时，组合物可用于染发。