1'-benzyl-1-hydroxy-2,2'-spirobiindan-1-one | 860756-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1'-benzyl-1-hydroxy-2,2'-spirobiindan-1-one
• 英文别名: 1'-benzyl-1'-hydroxy-1',3'-dihydro-3H-[2,2']spirobiinden-1-one；1'-Benzyl-1'-hydroxy-1',3'-dihydro-3H-[2,2']spirobiinden-1-on；3-benzyl-3-hydroxyspiro[1H-indene-2,2'-3H-indene]-1'-one
• CAS: 860756-40-7
• 化学式: C₂₄H₂₀O₂
• 分子量: 340.422
• InChiKey: SKOHDNSJRAAEFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1'-benzyl-1-hydroxy-2,2'-spirobiindan-1-one 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 14.0h， 以53%的产率得到1'-(E-benzylidene)-2,2'-spirobiindan-1-one
  参考文献：
  名称：

  Stereoselective Synthesis of α,α′‐Spirane‐Bridged Dibenzyl Ligands

  摘要：

  Benzylation in the alpha,alpha'-positions in the benzospirane, 2,2'-spirobiindane in a cis,cis manner has been effected from the corresponding diketone. Initial Grignard reactions and subsequent water elimination provided a stereoisomeric mixture of alpha,alpha'-alkylidene intermediates, which were stereoselectively hydrogenated to cis,cis-dibenzyl derivatives. The structure of intermediates in the reaction sequence has been ascertained by X-ray analyses.

  DOI：

  10.1080/00397910500186250
• 作为产物：
  描述：

  2,2'-spirobiindan-1,1'-dione 、 苄基氯化镁 在 乙醚 、 苯 作用下， 生成 1'-benzyl-1-hydroxy-2,2'-spirobiindan-1-one
  参考文献：
  名称：

  Leuchs; Lock, Chemische Berichte, 1915, vol. 48, p. 1437

  摘要：

  DOI：

文献信息

• Stereoselective Synthesis of α,α′‐Spirane‐Bridged Dibenzyl Ligands
  作者：Guixian Hu、Christian Rømming、Kjell Undheim

  DOI：10.1080/00397910500186250

  日期：2005.9.1

  Benzylation in the alpha,alpha'-positions in the benzospirane, 2,2'-spirobiindane in a cis,cis manner has been effected from the corresponding diketone. Initial Grignard reactions and subsequent water elimination provided a stereoisomeric mixture of alpha,alpha'-alkylidene intermediates, which were stereoselectively hydrogenated to cis,cis-dibenzyl derivatives. The structure of intermediates in the reaction sequence has been ascertained by X-ray analyses.
• Leuchs; Lock, Chemische Berichte, 1915, vol. 48, p. 1437
  作者：Leuchs、Lock

  DOI：——

  日期：——