1-(4-((3-(5-chloro-2,4-dihydroxyphenyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)methyl)phenyl)pyrrolidin-2-one | 1228282-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-((3-(5-chloro-2,4-dihydroxyphenyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)methyl)phenyl)pyrrolidin-2-one
• 英文别名: 1-[4-[[3-(5-Chloro-2,4-dihydroxyphenyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]methyl]phenyl]pyrrolidin-2-one
• CAS: 1228282-03-8
• 化学式: C₂₃H₂₃ClN₄O₃
• 分子量: 438.914
• InChiKey: YDBUQLYVMSPRTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  92.7
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] BICYCLIC PYRAZOLE AND ISOXAZOLE DERIVATIVES AS ANTITUMOR AND ANTINEURODEGENERATIVE AGENTS<br/>[FR] DÉRIVÉS BICYCLIQUES DE PYRAZOLE ET D'ISOXAZOLE EN TANT QU'AGENTS ANTITUMORAUX ET ANTINEURODÉGÉNÉRATIFS
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2010060854A1

  公开（公告）日：2010-06-03

  Bicyclic pyrazole and isoxazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases mediated by HSP90 protein, like cancer and neurodegenerative disorders.

  公开了式（I）的双环吡唑和异噁唑衍生物及其药学上可接受的盐，如规范中所定义的，以及其制备方法和包括它们的药物组合物；本发明的化合物可能在治疗由HSP90蛋白介导的疾病，如癌症和神经退行性疾病的治疗中有用。
• BICYCLIC PYRAZOLE AND ISOXAZOLE DERIVATIVES AS ANTITUMOR AND ANTINEURODEGENERATIVE AGENTS
  申请人：Mantegani Sergio

  公开号：US20110294790A1

  公开（公告）日：2011-12-01

  Bicyclic pyrazole and isoxazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases mediated by HSP90 protein, like cancer and neurodegenerative disorders.

  本发明揭示了式（I）的双环吡唑和异噁唑衍生物及其药学上可接受的盐，其定义详见规范，以及其制备方法和包含它们的制药组合物；本发明中的化合物可能在治疗由HSP90蛋白介导的疾病，如癌症和神经退行性疾病中有用。
• US8309578B2
  申请人：——

  公开号：US8309578B2

  公开（公告）日：2012-11-13