N-methyl-4,4-bis(4-phenylmethoxyphenyl)pentan-1-amine | 184866-19-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-4,4-bis(4-phenylmethoxyphenyl)pentan-1-amine
• CAS: 184866-19-1
• 化学式: C₃₂H₃₅NO₂
• 分子量: 465.635
• InChiKey: GIKNRVBAUXEUSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methyl-4,4-bis(4-phenylmethoxyphenyl)pentan-1-amine 在 sodium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 N-[4,4-bis(4-phenylmethoxyphenyl)pentyl]-N-methyl-4-sulfanylbenzamide
  参考文献：
  名称：

  Synthesis of a Series of Focally-Substituted Organothiol Dendrons

  摘要：

  The synthesis of new organothiol-functionalized dendrons of generation 1-4 is described. Several modifications to the original method for preparation of dendrons are detailed that were found to improve the yield and aid in scale-up. A particularly advantageous method for preparation of an aromatic thiol is reported and is employed in this reaction sequence. Several uses of these dendrons are anticipated and briefly described.

  DOI：

  10.1021/jo961527q
• 作为产物：
  描述：

  双酚酸 在 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 18-冠醚-6 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 、 丙酮 为溶剂， 反应 91.0h， 生成 N-methyl-4,4-bis(4-phenylmethoxyphenyl)pentan-1-amine
  参考文献：
  名称：

  Synthesis of a Series of Focally-Substituted Organothiol Dendrons

  摘要：

  The synthesis of new organothiol-functionalized dendrons of generation 1-4 is described. Several modifications to the original method for preparation of dendrons are detailed that were found to improve the yield and aid in scale-up. A particularly advantageous method for preparation of an aromatic thiol is reported and is employed in this reaction sequence. Several uses of these dendrons are anticipated and briefly described.

  DOI：

  10.1021/jo961527q

文献信息

• Synthesis of a Series of Focally-Substituted Organothiol Dendrons
  作者：Kang-Yi Chen、Christopher B. Gorman

  DOI：10.1021/jo961527q

  日期：1996.1.1

  The synthesis of new organothiol-functionalized dendrons of generation 1-4 is described. Several modifications to the original method for preparation of dendrons are detailed that were found to improve the yield and aid in scale-up. A particularly advantageous method for preparation of an aromatic thiol is reported and is employed in this reaction sequence. Several uses of these dendrons are anticipated and briefly described.