(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid 4-amino-phenyl ester | 207989-20-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid 4-amino-phenyl ester
• CAS: 207989-20-6
• 化学式: C₂₀H₂₄N₂O₅
• 分子量: 372.421
• InChiKey: JRDQRHLVEZETJE-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.02
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  110.88
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid 4-amino-phenyl ester 在 palladium on activated charcoal 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 3.0h， 生成 (S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid 4-guanidino-phenyl ester; compound with toluene-4-sulfonic acid
  参考文献：
  名称：

  Methyltrypsin-Catalyzed Peptide Coupling: Comparison of Alkyl Ester and Guanidinophenyl Ester Derivatives as Acyl Donor Component

  摘要：

  Methyltrypsin-catalyzed peptide synthesis has been studied by using conventional alkyl ester and p-guanidinophenyl ester derivatives of alpha-amino acid as the acyl donor component. They were found to be coupled with alpha-amino acid derivatives (acyl acceptor component) to produce dipeptide. The behavior of methyltrypsin toward both the substrates has been studied. (C) 1997 Academic Press.

  DOI：

  10.1006/bioo.1997.1076
• 作为产物：
  描述：

  4-硝基苯基N-{[(2-甲基-2-丙基)氧基]羰基}-L-酪氨酸酯 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 20.0h， 生成 (S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid 4-amino-phenyl ester
  参考文献：
  名称：

  Methyltrypsin-Catalyzed Peptide Coupling: Comparison of Alkyl Ester and Guanidinophenyl Ester Derivatives as Acyl Donor Component

  摘要：

  Methyltrypsin-catalyzed peptide synthesis has been studied by using conventional alkyl ester and p-guanidinophenyl ester derivatives of alpha-amino acid as the acyl donor component. They were found to be coupled with alpha-amino acid derivatives (acyl acceptor component) to produce dipeptide. The behavior of methyltrypsin toward both the substrates has been studied. (C) 1997 Academic Press.

  DOI：

  10.1006/bioo.1997.1076