L-asparaginyl-L-phenylalanyl-L-phenylananyl-L-tryptophanyl-L-lysine | 76521-36-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-asparaginyl-L-phenylalanyl-L-phenylananyl-L-tryptophanyl-L-lysine
• CAS: 76521-36-3
• 化学式: C₃₉H₄₈N₈O₇
• 分子量: 740.86
• InChiKey: TXHVTCHEWNMGER-FLIXOAOSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.55
• 重原子数：
  54.0
• 可旋转键数：
  21.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  264.62
• 氢给体数：
  9.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  丁氧羰基-L-天冬酰胺对硝苯基酯 、 BOC-L-苯丙氨酸 、 N-叔丁氧羰基-N'-(2-氯苄氧羰基)-L-赖氨酸 、 N-叔丁氧羰基-L-色氨酸 生成 L-asparaginyl-L-phenylalanyl-L-phenylananyl-L-tryptophanyl-L-lysine
  参考文献：
  名称：

  Solid-phase synthesis of two glycopeptides containing the amino acid sequence 5 to 9 of somatostatin

  摘要：

  2,3,4,6-Tetra-O-acetyl-1-N-[N-(tert-butyloxycarbonyl)-L-aspart-4-oyl]-D-g lucopyranosylamine and 2-acetamido-3,4,6-tri-O-acetyl-1-N-[N-(tert-butyloxycarbonyl)-L-aspart-4-oyl]-2 -deoxy-D-glucopyranosylamine were introduced, respectively, by the solid-phase procedure in the amino acid sequence 5 to 9 of somatostatin. The two resulting glycopeptides beta-D-Glcp-(1 leads to 4)- and beta-D-GlcpNAc-(1 leads to 4)-Asn-Phe-Phe-Trp-Lys-OH were homogeneous on examination by t.l.c. and l.c., and their structures were confirmed by m.s. of the N-acetyl, permethyl derivatives.

  DOI：

  10.1016/s0008-6215(00)85247-7