1-[4-(4-fluoro-phenyl)-1H-imidazol-2-yl]-ethylamine | 1057215-43-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[4-(4-fluoro-phenyl)-1H-imidazol-2-yl]-ethylamine
• 英文别名: (1S)-1-[5-(4-fluorophenyl)-1H-imidazol-2-yl]ethanamine
• CAS: 1057215-43-6
• 化学式: C₁₁H₁₂FN₃
• 分子量: 205.235
• InChiKey: BZQHDPSKUBNQPA-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PEPTIDOMIMETIC PROTEASOME INHIBITORS<br/>[FR] INHIBITEURS PEPTIDOMIMÉTIQUES DU PROTÉASOME
  申请人：UNIV CORNELL

  公开号：WO2019075252A1

  公开（公告）日：2019-04-18

  The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I'): where the substituents R, R1, R3 R4, R', W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由具有式（I）和式（I'）的以下化合物表示：其中取代基R、R1、R3、R4、R'、W、X、Y、Z、k和m如本文所定义，取代基R、R1、R2、R3、R4、X、Y、Z和m如本文所定义。这些化合物用于治疗细菌感染、寄生虫感染、真菌感染、癌症、免疫紊乱、自身免疫性疾病、神经退行性疾病和紊乱、炎症性疾病，或肌肉萎缩症，或用于为移植的器官或组织提供免疫抑制。
• NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
  申请人：Breslin J. Henry

  公开号：US20080096888A1

  公开（公告）日：2008-04-24

  The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.

  本发明涉及式(I)的新型阿片受体调节剂。本发明还涉及制备这些化合物的方法、含有它们的药物组合物以及它们在治疗可能通过调节阿片受体改善或治疗的疾病中的应用。
• Opioid receptor modulators
  申请人：Janssen Pharmaceutica NV

  公开号：EP2298744A2

  公开（公告）日：2011-03-23

  The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.

  本发明涉及式（I）的新型阿片受体调节剂。 本发明还涉及制备此类化合物的方法、含有此类化合物的药物组合物，以及它们在治疗可通过调节阿片受体来改善或治疗的疾病中的用途。
• Peptidomimetic proteasome inhibitors
  申请人：CORNELL UNIVERSITY

  公开号：US11203613B2

  公开（公告）日：2021-12-21

  The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I′): where the substituents R, R1, R3 R4, R′, W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由具有式（I）和式（I′）的下列化合物表示：其中取代基R、R1、R3 R4、R′、W、X、Y、Z、k和m如本文所定义，取代基R、R1、R2、R3、R4、X、Y、Z和m如本文所定义。这些化合物可用于治疗细菌感染、寄生虫感染、真菌感染、癌症、免疫性疾病、自身免疫性疾病、神经退行性疾病、炎症性疾病或肌肉萎缩症，或为移植器官或组织提供免疫抑制。
• Process for preparing intermediates of compounds useful as opioid receptor modulators
  申请人：Janssen Pharmaceutica NV

  公开号：EP2573068B1

  公开（公告）日：2014-12-31