| 1242182-22-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1242182-22-4
• 化学式: C₂₁H₁₈N₁₂O₆
• 分子量: 534.451
• InChiKey: HEEHVHOVCPONSM-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 、 三乙胺 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 生成 6,13,20-Tris(aminomethyl)-22,23,24-trioxa-3,10,17-triazatetracyclo[17.2.1.15,8.112,15]tetracosa-1(21),5,7,12,14,19-hexaene-2,9,16-trione
  参考文献：
  名称：

  Furan based cyclic homo-oligopeptides bind G-quadruplex selectively and repress c-MYC transcription

  摘要：

  We demonstrate the synthesis and selective binding of two novel furan based tricyclic homo-oligopeptides to G-quadruplex and using Real Time PCR show its repressive effect on c-MYC transcription. CD spectroscopy and FRET melting studies show that these ligands can induce G-quadruplex structures in the G rich 22 mer c-MYC DNA sequence and further stabilize the structure. Using real time polymerase chain reaction we observed that up to 70% downregulation of c-MYC transcripts upon ligand treatment in HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.080
• 作为产物：
  描述：

  在 五氟苯基二苯基磷酸酯 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以850 mg的产率得到
  参考文献：
  名称：

  Furan based cyclic homo-oligopeptides bind G-quadruplex selectively and repress c-MYC transcription

  摘要：

  We demonstrate the synthesis and selective binding of two novel furan based tricyclic homo-oligopeptides to G-quadruplex and using Real Time PCR show its repressive effect on c-MYC transcription. CD spectroscopy and FRET melting studies show that these ligands can induce G-quadruplex structures in the G rich 22 mer c-MYC DNA sequence and further stabilize the structure. Using real time polymerase chain reaction we observed that up to 70% downregulation of c-MYC transcripts upon ligand treatment in HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.080