双(Alpha,2-二氯亚苄基)肼 | 792-39-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双(Alpha,2-二氯亚苄基)肼
• 中文别名: 双(Α,2-二氯亚苄基)肼
• 英文名称: 1,2-Di[chloro(2-chlorophenyl)methylidene]hydrazine
• 英文别名: (NZ,1Z)-2-chloro-N-[chloro-(2-chlorophenyl)methylidene]benzenecarbohydrazonoyl chloride
• CAS: 792-39-2
• 化学式: C₁₄H₈Cl₄N₂
• 分子量: 346.043
• InChiKey: STSYYFNBAHTXBF-AXPXABNXSA-N

物化性质

• 溶解度：
  溶于二氯甲烷

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

制备方法与用途

化学性质 

双(α，2-二氯亚苄基)肼纯品为无色或微黄色结晶体，m.p.103～105℃，相对密度0.93，溶于甲醇、二氯乙烷、冰醋酸、丙酮和四氯化碳等有机溶剂。

用途 

双(α，2-二氯亚苄基)肼是合成杀螨剂四螨嗪的重要中间体。

生产方法 

双(α，2-二氯亚苄基)肼是由双(2-氯亚苄基)肼和氯气为原料制得。

将342 L，冰醋酸和53 L乙酐投入氯化釜中，打开固体投料口投入105kg双(2-氯亚苄基)肼，然后关闭投料口，开启冷冻，当反应液温度降至20℃左右时开始通氯气，控制反应温度在20～30℃，通氯气量95kg。通氯气完毕后保温16h，保温结束后，曝气，然后将反应物料放入过滤器过滤，滤液送人蒸馏釜蒸馏，回收乙酸供套用，残液焚烧，滤饼经少量水洗涤，干燥。

反应信息

• 作为反应物：
  描述：

  双(Alpha,2-二氯亚苄基)肼 在 一水合肼 、 溶剂黄146 、 sodium nitrite 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 2.75h， 生成 四螨嗪
  参考文献：
  名称：

  Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives

  摘要：

  Fourteen compounds of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives were prepared and their structures were confirmed by single-crystal X-ray diffraction and the semi-empirical calculation of PM3 method. This reaction yields the 1,4-dihydro derivatives rather than the 1,2.-dihydro derivatives. The central six-membered ring of 1,4-dihydro-1,2,4,5-tetrazine has a chair conformation and therefore is not homoaromatic. Their antitumor activities were evaluated in vitro by SRB method for A-549 and BEL-7402 cells, and MTT method for P-388 and HL-60 cells. The results show that there is one compound which is highly effective against P-388 cells and one compound which is highly effective against HL-60 cells. So it is a kind of compound which possesses potential antitumor activities and is worth to research further. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.04.066
• 作为产物：
  描述：

  N,N'-bis-(2-chloro-benzoyl)-hydrazine 生成 双(Alpha,2-二氯亚苄基)肼
  参考文献：
  名称：

  PARSONS, J. H.

  摘要：

  DOI：

文献信息

• Acaricidal, larvicidal and ovicidal tetrazine derivatives and compositions, processes for their preparation and methods of using them
  申请人：FBC LIMITED

  公开号：EP0005912A1

  公开（公告）日：1979-12-12

  The substituted tetrazines of the formula: and of the formula: wherein: R1, R2 and R4 each represent hydrogen, phenyl, alkyl of 1 to 6 carbon atoms, or alkenyl or alkynyl of 3 to 6 carbon atoms, each of which may be unsubstituted or substituted by one or more halogen atoms, hydroxy groups, cyano groups, carboxy groups, alkoxycarbonyl groups of 2 to 5 carbon atoms, or alkoxy groups of 1 to 4 carbon atoms; or R1 and R2 together represent a single bond; R3 represents alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl, or phenylalkyl of 7 to 10 carbon atoms, each of which may be unsubstituted or substituted by one or more halogen atoms, alkyl or alkoxy groups of 1 to 6 carbon atoms, nitro groups, cyano groups, mercapto groups, or alkyl-mercapto groups of 1 to 4 carbon atoms; and R6 represents a phenyl group substituted in at least the 2-position by fluorine, chlorine,. bromine or iodine; are effective to combat acarids and their eggs. Most of the compounds are new and processes for their preparation are described.

  式的取代四嗪： 和式 其中R1、R2 和 R4 各自代表氢、苯基、1 至 6 个碳原子的烷基或 3 至 6 个碳原子的烯基或炔基，其中每个基团可以未被取代或被一个或多个卤素原子、羟基、氰基、羧基、2 至 5 个碳原子的烷氧羰基或 1 至 4 个碳原子的烷氧基取代；或 R1 和 R2 一起代表单键；R3 代表 1 至 6 个碳原子的烷基、3 至 7 个碳原子的环烷基、苯基或 7 至 10 个碳原子的苯基烷基，其中每个烷基可以未被取代，也可以被一个或多个卤素原子、1 至 6 个碳原子的烷基或烷氧基、硝基、氰基、巯基或 1 至 4 个碳原子的烷基-巯基取代；以及 R6 代表至少在 2 位被氟、氯、溴或碘取代的苯基。溴或碘取代的苯基；可有效防治螨虫及其虫卵。 大多数化合物都是新化合物，并介绍了其制备过程。
• Electric cables and compositions for use in them
  申请人：BICC Public Limited Company

  公开号：EP0058022A1

  公开（公告）日：1982-08-18

  A low-tack, non-cell filling filling medium for telecommunication cables comprises in parts (by weight):- (a) 70 - 98% of a hydrocarbon base; (b) 1 - 15% of a block copolymer which comprises at least one block tending to confer solubility in the base and at least one block tending to inhibit such solubility, the proportions of the blocks being such that the polymer shows a strong tendency to form a gel with the base; and (c) 1 - 15% of a hydrocarbon material that is miscible with the medium at high temperatures but forms solid dispersed particles on cooling at a temperature not lower than 65°C: the base (a) comprising: (i) 0 - 95% of a mineral oil with or without wax, for example in the form of petroleum jelly; and (ii) 5 - 100% of a hydrocarbon or hydrocarbon mixture whose molecules are substantially incapable of diffusing into polyethylene, polypropylene or other cellular insulating material at temperatures of up to 80°C and, when mineral oil is present being soluble in it and having a low enough (number average) molecular weight to reduce significantly the osmotic pressure of the medium.

  一种用于电信电缆的低粘性、非电池填充的填充介质包括以下部分（按重量计）： - 电缆 (a) 70-98%的烃基； (b) 1-15%的嵌段共聚物，其中至少有一个嵌段倾向于赋予在基质中的溶 解性，至少有一个嵌段倾向于抑制这种溶解性，嵌段的比例应使聚合物显 示出与基质形成凝胶的强烈倾向；以及 (c) 1-15%的烃类材料，这种材料在高温下可与介质混溶，但在不低于 65°C 的温度下冷却时会形成固体分散颗粒： 基料(a)包括 (i) 0-95%的矿物油，含蜡或不含蜡，例如凡士林形式；和 (ii) 5-100%的碳氢化合物或碳氢化合物混合物，其分子在高达 80℃的温 度下基本上不能扩散到聚乙烯、聚丙烯或其他蜂窝状绝缘材料中，如 果含有矿物油，则可溶于矿物油，并具有足够低的分子量（平均数）， 以显著降低介质的渗透压。
• ——
  作者：

  DOI：——

  日期：——
• Novel acaricidally active tetrazine derivatives
  申请人：CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

  公开号：EP0635499B1

  公开（公告）日：1999-03-03
• Pesticidal heterocyclic compounds, processes for preparing them, compositions containing them, and their use
  申请人：FBC LIMITED

  公开号：EP0036711B1

  公开（公告）日：1985-12-04