(E)-14-amino-tetradec-2-enoic acid hydrochloride | 1042499-01-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-14-amino-tetradec-2-enoic acid hydrochloride
• 英文别名: [(E)-13-carboxytridec-12-enyl]azanium;chloride
• CAS: 1042499-01-3
• 化学式: C₁₄H₂₇NO₂*ClH
• 分子量: 277.835
• InChiKey: ZJLRETHORGKLOM-VHPXAQPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.91
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY
  申请人：Tarroux Roger

  公开号：US20100240754A1

  公开（公告）日：2010-09-23

  The present invention relates to drugs consisting of unsaturated fatty amino-acid derivatives of the general formula (I), and to their pharmaceutically acceptable acid addition salts, in which: X is oxygen or NH, Rn are independently hydrogen or a (C 1 -C 6 )alkyl optionally substituted by halogen; R 1 is hydrogen, fluorine, chlorine or bromine, or a CF 3 or CHF 2 or a (C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl or (C 1 -C 6 )alkynyl, optionally substituted by one or more halogen atoms; R is hydrogen or a (C 1 -C 6 )alkyl or (C 3 -C 6 )cycloalkyl optionally substituted by one or more halogen atoms; Ra and Rb are independently hydrogen (C 1 -C 6 )alkyl or (C 1 -C 6 )acyl, and Ra and Rb a hydrocarbonated cycle containing 4 to 6 carbon atoms; and n is an integer between 2 and 14.

  本发明涉及一种由通式（I）的不饱和脂肪氨基酸衍生物组成的药物，以及它们的药用可接受的酸盐，其中：X为氧或NH，Rn独立地为氢或经卤素取代的（C1-C6）烷基；R1为氢、氟、氯或溴，或者为CF3或CHF2或（C1-C6）烷基、（C1-C6）烯基或（C1-C6）炔基，可以经过一个或多个卤素原子的取代；R为氢或者经过一个或多个卤素原子取代的（C1-C6）烷基或（C3-C6）环烷基；Ra和Rb独立地为氢、（C1-C6）烷基或（C1-C6）酰基，而Ra和Rb为含有4到6个碳原子的碳氢化合物环；n为介于2和14之间的整数。