11-sulfonic undecanoic acid | 91243-93-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-sulfonic undecanoic acid
• 英文别名: 11-sulfoundecanoic acid；11-sulfo-undecanoic acid；11-Sulfo-undecansaeure；Undecansaeure-(1)-sulfonsaeure-(11)；11-Sulfo-undecylsaeure；11-sulfohendecanoic acid
• CAS: 91243-93-5
• 化学式: C₁₁H₂₂O₅S
• 分子量: 266.359
• InChiKey: HODIOTABVUHCTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  11-sulfonic undecanoic acid 在 硫酸 、 双氧水 作用下， 反应 1.5h， 生成 11-sulfoundecaneperoxoic acid
  参考文献：
  名称：

  [EN] SULFOPEROXYCARBOXYLIC ACIDS, THEIR PREPARATION AND METHODS OF USE AS BLEACHING AND ANTIMICROBIAL AGENTS
  [FR] ACIDES PEROXYCARBOXYLIQUES SULFURÉS, LEUR PRÉPARATION ET LEURS PROCÉDÉS D'UTILISATION EN TANT QU'AGENTS DE BLANCHIMENT ET ANTIMICROBIENS

  摘要：

  公开号：

  WO2009118714A3
• 作为产物：
  描述：

  11-巯基十一烷酸 在 air 、 金 作用下， 反应 2.0h， 生成 11-sulfonic undecanoic acid
  参考文献：
  名称：

  Deep UV Photopatterning of Biphenyl Thiol Self-Assembled Monolayer and its Physical Properties

  摘要：

  Aromatic thiol such as a 4'-mercapto-biphenyl-4-carboxylic acid was synthesized, and then the self-assembled monolayer (SAM) was fabricated on a gold substrate. The pattern formation of biphenyl thiol and alkanethiol SAMs was obtained by oxidation reaction due to the irradiation of deep UV light. The resulting positive pattern image and current-voltage (I-V) characteristics of biphenyl thiol and alkanethiols were investigated through the measurements of Atomic Force Microscope (AFM) and Scanning Tunneling Microscope (STM). In addition, cytochrome c protein was immobilized onto the patterned gold substrate by self-assembly technique and electrochemical activity was studied with a cyclic voltammetry.

  DOI：

  10.1080/15421400601027981

文献信息

• Acid monolayer functionalized iron oxide nanoparticles as catalysts for carbohydrate hydrolysis
  作者：Myles Ikenberry、Leidy Peña、Daming Wei、Hongwang Wang、Stefan H. Bossmann、Trenton Wilke、Donghai Wang、Venugopal R. Komreddy、D. Paul Rillema、Keith L. Hohn

  DOI：10.1039/c3gc41420e

  日期：——

  Superparamagnetic iron oxide nanoparticles were functionalized with a quasi-monolayer of 11-sulfoundecanoic acid and 10-phosphono-1-decanesulfonic acid ligands to create separable solid acid catalysts. The ligands are bound through carboxylate or phosphonate bonds to the magnetite core. The ligand-core bonding surface is separated by a hydrocarbon linker from an outer surface with exposed sulfonic acid groups. The more tightly packed monolayer of the phosphonate ligand corresponded to a higher sulfonic acid loading by weight, a reduced agglomeration of particles, a greater tendency to remain suspended in solution in the presence of an external magnetic field, and a higher catalytic activity per sulfonic acid group. The particles were characterized by thermogravimetric analysis (TGA), transmission electron microscopy (TEM), potentiometric titration, diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), inductively coupled plasma optical emission spectrometry (ICP-OES), and dynamic light scattering (DLS). In sucrose catalysis reactions, the phosphonic–sulfonic nanoparticles (PSNPs) were seen to be incompletely recovered by an external magnetic field, while the carboxylic–sulfonic nanoparticles (CSNPs) showed a trend of increasing activity over the first four recycle runs. The activity of the acid-functionalized nanoparticles was compared to the traditional solid acid catalyst Amberlyst-15 for the hydrolysis of starch in aqueous solution. Catalytic activity for starch hydrolysis was in the order PSNPs > CSNPs > Amberlyst-15. Monolayer acid functionalization of iron oxides presents a novel strategy for the development of recyclable solid acid catalysts.

  超级磁性氧化铁纳米颗粒被功能化，表面覆盖了近单层的11-硫代十酸和10-磷酸十烷基磺酸配体，从而创建了可分离的固体酸催化剂。这些配体通过羧酸盐或磷酸盐键结合于磁铁矿核心。配体与核心的结合表面通过碳氢链与外表面分隔，外表面暴露有磺酸基团。更紧密排列的磷酸盐配体单层对应于更高的重量磺酸负载、较低的颗粒聚集、在外部磁场存在下更强的悬浮能力，以及每个磺酸基团更高的催化活性。通过热重分析（TGA）、透射电子显微镜（TEM）、电位滴定、漫反射红外傅里叶变换光谱（DRIFTS）、感应耦合等离子体光发射光谱（ICP-OES）和动态光散射（DLS）对颗粒进行了表征。在蔗糖催化反应中，磷酸–磺酸纳米颗粒（PSNPs）在外部磁场影响下回收不完全，而羧酸–磺酸纳米颗粒（CSNPs）在前四次循环中呈现出活性增加的趋势。酸功能化纳米颗粒的活性与传统固体酸催化剂Amberlyst-15在水溶液中水解淀粉的效果进行了比较。淀粉水解的催化活性顺序为PSNPs > CSNPs > Amberlyst-15。铁氧化物的单层酸功能化为开发可回收固体酸催化剂提供了一种新颖的策略。
• ALBUMIN BINDING PROBES AND DRUG CONJUGATES THEREOF
  申请人：Shechter Yoram

  公开号：US20150202310A1

  公开（公告）日：2015-07-23

  The present invention provides a long chain fatty acid (LCFA)-like albumin-binding probe/ligand containing no hydrolysable bond and having an enhanced associating affinity with human serum albumin, which upon conjugation with an amino- or mercapto-containing short-lived drug and administration of the conjugate, significantly prolongs the life time of said drug without substantially interfering with its pharmacological activity. The invention further provides conjugates of said probe with amino- or mercapto-containing drugs, as well as pharmaceutical compositions and uses thereof.

  本发明提供了一种长链脂肪酸（LCFA）类似的结合白蛋白探针/配体，不含可水解键，与人类血清白蛋白具有增强的结合亲和力，将其与含氨基或巯基的短寿药物结合并给药后，显著延长所述药物的寿命，且基本不干扰其药理活性。该发明还提供了所述探针与含氨基或巯基药物的结合物，以及其制剂组合和用途。
• Strategies in the Design of Solution-Stable, Water-Soluble Prodrugs I: A Physical-Organic Approach to Pro-Moiety Selection for 21-Esters of Corticosteroids
  作者：B.D. Anderson、R.A. Conradi、K.E. Knuth

  DOI：10.1002/jps.2600740402

  日期：1985.4

  the design of solution-stable, water-soluble prodrugs of corticosteroids has been developed. Two key requirements for dilute solution stability are high solubility at the pH of optimum stability and appropriate design of the pH-rate profile. Several 21-esters of methylprednisolone have been synthesized, and the rates of their aqueous solution hydrolysis have been determined to test the strategy. Compounds

  理想的水溶性前药应表现出足够的水溶液稳定性以使其溶液能够长期保存（即在室温下可保存2年），但应在体内迅速转化为活性母体药物-两种严重且看似相互矛盾的药物要求限制了许多常见的增溶部分的实用性。例如，通常用作水溶性前药的琥珀酸酯在溶液中不稳定，并且在体内可能经历缓慢和不完全的生物转化。在这项研究中，对与21个皮质类固醇激素有关的溶液稳定性问题进行了综述。结论是，最重要的限制货架寿命的反应是酯水解。考虑到分子结构对酯反应性的影响，设计了溶液稳定的策略，已经开发了皮质类固醇的水溶性前药。稀溶液稳定性的两个关键要求是：在最佳稳定性的pH值下具有高溶解度，以及对pH速率分布进行适当设计。已经合成了几个21-酯的甲基强的松龙，并确定了其水溶液的水解速率以测试该策略。已鉴定出在25摄氏度下在稀溶液中显示超过2年的估计货架寿命的化合物。
• SULFOPEROXYCARBOXYLIC ACIDS, THEIR PREPARATION AND METHODS OF USE AS BLEACHING AND ANTIMICROBIAL AGENTS
  申请人：Li Junzhong

  公开号：US20100021557A1

  公开（公告）日：2010-01-28

  The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.

  本发明涉及新型磺酰过氧羧酸化合物及其制备和使用方法。本发明的磺酰过氧羧酸化合物具有储存稳定性、水溶性和低至无气味。此外，本发明的化合物可由非石油基可再生材料制成。本发明的化合物可用作抗菌剂和漂白剂。本发明的化合物也适用于用作偶联剂。
• DETERGENTS CAPABLE OF CLEANING, BLEACHING, SANITIZING AND/OR DISINFECTING TEXTILES INCLUDING SULFOPEROXYCARBOXYLIC ACIDS
  申请人：Gohl David W.

  公开号：US20120225943A1

  公开（公告）日：2012-09-06

  The present invention relates to novel combined laundry detergent, bleach, and antimicrobial composition incorporating novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds used in compositions of the invention are storage stable, water soluble and have low to no odor. Compositions of the invention may be in the form of a liquid, a solid, or a gel. The sulfoperoxycarboxylic compounds useful in preparing compositions of the present invention can be formed from non-petroleum based renewable materials.

  本发明涉及一种新型的组合洗涤剂、漂白剂和抗菌剂组合物，其中包括新型的磺基过氧羧酸化合物，并提供制备和使用它们的方法。本发明中使用的磺基过氧羧酸化合物具有储存稳定性、水溶性和低至无气味。本发明中的组合物可以是液体、固体或凝胶。本发明中用于制备组合物的磺基过氧羧酸化合物可以由非石油基可再生材料形成。