2-[(2-Fluorophenyl)methyl]-1,3-thiazole-5-carboxylic acid | 1018297-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[(2-Fluorophenyl)methyl]-1,3-thiazole-5-carboxylic acid
• CAS: 1018297-66-9
• 化学式: C₁₁H₈FNO₂S
• mdl: MFCD10008833
• 分子量: 237.25
• InChiKey: DKFZXXPYPJEKOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
  申请人：LES LABORATOIRES SERVIER

  公开号：US10654849B2

  公开（公告）日：2020-05-19

  Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.

  式(I)化合物： 其中 R1、R2、J、K、L、n 和 W 如说明中所定义。 含有相同成分的医药产品，可用于治疗需要促凋亡剂和/或抗增生剂的病症。
• NEW (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Les Laboratoires Servier

  公开号：EP3468971A1

  公开（公告）日：2019-04-17
• (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：LES LABORATOIRES SERVIER

  公开号：US20190144449A1

  公开（公告）日：2019-05-16

  Compounds of formula (I): wherein R 1 , R 2 , J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.