4,4'-Dihydroxy-3,3'-diacetyl-biphenyl | 13938-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-Dihydroxy-3,3'-diacetyl-biphenyl
• 英文别名: 4,4'-Dihydroxy-3,3'-diacetyl biphenyl；1-[5-(3-acetyl-4-hydroxyphenyl)-2-hydroxyphenyl]ethanone
• CAS: 13938-28-8
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: MHZOXWCTOKMKQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4'-Dihydroxy-3,3'-diacetyl-biphenyl 在 碘 、 sodium hydride 作用下， 以 四氢呋喃 、 二甲基亚砜 、 mineral oil 为溶剂， 反应 25.25h， 生成 Bis-<2-(4-methoxyphenyl)-chromen-4-on-6-yl>
  参考文献：
  名称：

  Synthesis and antifungal activities of natural and synthetic biflavonoids

  摘要：

  The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.04.010
• 作为产物：
  描述：

  4,4'-双乙酰联苯 在 aluminum (III) chloride 、 盐酸 作用下， 以 氯苯 、 水 为溶剂， 反应 8.0h， 以72%的产率得到4,4'-Dihydroxy-3,3'-diacetyl-biphenyl
  参考文献：
  名称：

  Synthesis and antifungal activities of natural and synthetic biflavonoids

  摘要：

  The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.04.010

文献信息

• The Preparation of Some New Alkylphenols¹
  作者：R. W. Stoughton、R. Baltzly、A. Bass

  DOI：10.1021/ja01324a505

  日期：1934.9
• Madhvi; Karia; Parsania, Journal of the Indian Chemical Society, 2009, vol. 86, # 6, p. 588 - 593
  作者：Madhvi、Karia、Parsania

  DOI：——

  日期：——
• A novel biphenyl-derived salicylhydrazone Schiff base fluorescent probes for identification of Cu2+ and application in living cells
  作者：Yun-Shang Yang、Suo-Suo Ma、Ying-Peng Zhang、Jia-Xi Ru、Xiao-Yu Liu、Hui-Chen Guo

  DOI：10.1016/j.saa.2018.03.060

  日期：2018.6

  A novel biphenyl-derived salicylhydrazone Schiff base (BSS) fluorescent probes for highly sensitive and selective identification of Cu2+ has been synthesized. In addition, the recognition has been proved experimentally. The results indicated that the complex forms a 1:1 complex with Cu2+ shows fluorescent quenching. Furthermore, the detection limit of 1.54 x 10(-8) M. More interesting, the probe BSS not only have a good biocompatibility in living cells, but also the sense behavior of Cu2+ in the cell nucleus. (C) 2018 Elsevier B.V. All rights reserved.
• Regioselective Tandem [4 + 1]–[4 + 2] Synthesis of Amino-Substituted Dihydroxanthones and Xanthones
  作者：Ana Bornadiego、Jesús Díaz、Carlos F. Marcos

  DOI：10.1021/acs.joc.5b00658

  日期：2015.6.19

  A highly convergent and operationally simple approach to mycotoxin-related 4-amino-substituted 1-hydroxy-dihydroxanthones is described. The target compounds are obtained in one pot by the multicomponent reaction of 3-carbonylchromones, isocyanides, and nonsymmetric dienophiles. The reaction, which involves a tandem [4 + 1]-[4 + 2] cydoaddition, efficiently affords a variety of both monomeric and dimeric polysubstituted dihydroxanthones structurally similar to bioactive ergochromes. Further aromatization to the corresponding xanthones is readily achieved by treatment with DBU under microwave irradiation.
• Boon-Long, 1948, vol. 1, # 4, p. 5,9
  作者：Boon-Long

  DOI：——

  日期：——