4-氧代-1-哌啶乙酸苄酯 | 364056-14-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 4-氧代-1-哌啶乙酸苄酯
• 英文名称: phenylmethyl 2-(4-oxopiperidyl)acetate
• 英文别名: benzyl (4-oxopiperidin-1-yl)acetate；Benzyl 2-(4-oxopiperidin-1-yl)acetate
• CAS: 364056-14-4
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: NZJNMGYKSKNROE-UHFFFAOYSA-N

物化性质

• 沸点：
  392.1±32.0 °C(Predicted)
• 密度：
  1.164±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-5-(2-amino-1-(tert-butyldimethylsilyloxy)ethyl)-8-hydroxyquinolin-2(1H)-one 、 4-氧代-1-哌啶乙酸苄酯 在 溶剂黄146 、 三乙酰氧基硼氢化钠 、 氨 作用下， 以 N-甲基吡咯烷酮 、 异丙醇 、 乙腈 为溶剂， 反应 38.0h， 生成 benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate
  参考文献：
  名称：

  WO2007/102771

  摘要：

  公开号：
• 作为产物：
  描述：

  4-氧代哌啶酮盐酸盐 、 2-溴乙酸苄酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-氧代-1-哌啶乙酸苄酯
  参考文献：
  名称：

  WO2007/102771

  摘要：

  公开号：

文献信息

• Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
  申请人：NitroMed, Inc.

  公开号：US06297260B1

  公开（公告）日：2001-10-02

  The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

  本发明描述了新颖的硝化和/或亚硝化非甾体抗炎化合物，以及包含至少一种硝化和/或亚硝化非甾体抗炎化合物的新型组合物，还可以包含至少一种捐赠、转移或释放一氧化氮、提高内源性内皮源性舒张因子水平、刺激内源性一氧化氮合成或是一氧化氮合酶底物的化合物。本发明还提供了治疗、预防和/或减轻炎症、疼痛和发热的方法；减少或逆转使用非甾体抗炎药物导致的胃肠道、肾脏和其他毒性反应；治疗和/或预防胃肠道疾病；治疗炎症性疾病状态和疾病；以及治疗和/或预防眼科疾病或疾病的方法。
• Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositons and methods of use
  申请人：——

  公开号：US20020016322A1

  公开（公告）日：2002-02-07

  The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

  本发明描述了新型的亚硝酸化和/或亚硝基化的非甾体抗炎化合物，以及包含至少一种亚硝酸化和/或亚硝基化的非甾体抗炎化合物的新型组合物，以及可选地含有至少一种捐赠、转移或释放一氧化氮、提高内皮源性松弛因子内源水平、刺激内源性一氧化氮合成或是一氧化氮合酶底物的化合物。本发明还提供了治疗、预防和/或减轻炎症、疼痛和发热的方法；减少或逆转由非甾体抗炎药物使用引起的胃肠道、肾脏和其他毒性；治疗和/或预防胃肠道疾病；治疗炎症性疾病和疾病状态；以及治疗和/或预防眼科疾病或疾病状态。
• PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS
  申请人：Alcaraz Lilian

  公开号：US20090029958A1

  公开（公告）日：2009-01-29

  The present invention relates to compounds according to formula (I), a process for preparing them, the intermediate compounds of the process and the use of the compounds in the manufacture of a medicament for use in treating diseases such as ARDS, pulmonary emphysema, bronchitis, bronchiectasis, COPD, asthma and rhinitis. The compounds are beta2 adrenoreceptor agonists.

  本发明涉及公式（I）的化合物，其制备方法，该方法的中间体以及将该化合物用于制造用于治疗ARDS，肺气肿，支气管炎，支气管扩张，COPD，哮喘和鼻炎等疾病的药物的用途。这些化合物是β2肾上腺素能受体激动剂。
• Substituted spirocyclic inhibitors of autotaxin
  申请人：X-Rx, Inc.

  公开号：US10233182B2

  公开（公告）日：2019-03-19

  The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

  本发明涉及根据式 I 的化合物和药学上可接受的盐、合成、中间体、制剂以及用其治疗疾病的方法，包括至少部分由 ATX 介导的癌症、淋巴细胞归巢、慢性炎症、神经性疼痛、纤维化疾病、血栓形成和胆汁淤积性瘙痒症。
• Fused piperidine amides as modulators of ion channels
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US10233191B2

  公开（公告）日：2019-03-19

  The invention relates to fused piperidine amides useful as inhibitors of ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及可用作治疗疼痛的离子通道抑制剂的融合哌啶酰胺。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。