N'-cyclohexylidene-2-hydroxybenzohydrazide | 100615-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-cyclohexylidene-2-hydroxybenzohydrazide
• 英文别名: salicylic acid cyclohexylidenehydrazide；Salicylsaeure-cyclohexylidenhydrazid；Cyclohexanon-salicyloylhydrazon；N-(cyclohexylideneamino)-2-hydroxybenzamide
• CAS: 100615-79-0
• 化学式: C₁₃H₁₆N₂O₂
• 分子量: 232.282
• InChiKey: HBPTVARBHZVJLD-UHFFFAOYSA-N

物化性质

• 熔点：
  204-206 °C (decomp)(Solv: ethanol (64-17-5))
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  N'-cyclohexylidene-2-hydroxybenzohydrazide 在 硫酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 生成 2-Spiro[[1,3]thiazolo[4,3-b][1,3,4]oxadiazole-5,1'-cyclohexane]-2-ylphenol
  参考文献：
  名称：

  Agrawal, Taruna; Tiwari, Nirupama; Khan, M. H., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, # 6, p. 603 - 606

  摘要：

  DOI：
• 作为产物：
  描述：

  环己酮 、 水杨酰肼 137.0 ℃ 、250.0 kPa 条件下， 反应 0.07h， 以100%的产率得到N'-cyclohexylidene-2-hydroxybenzohydrazide
  参考文献：
  名称：

  Fast Synthesis of N-Acylhydrazones Employing a Microwave Assisted Neat Protocol

  摘要：

  A variety of N-acylhydrazones were synthesized Under microwave irradiation within 2.5-10 min, starting from benzo, salicyloyl, and isonicotinic hydrazides. The protocol developed employs microwave irradiation in the absence of solvents and catalysts, leading to high yields. The results are reproducible in a 500 mg to 5 g scale.

  DOI：

  10.1021/cc9001444

文献信息

• Coordination compounds of hydrazine derivatives with transition metals. X. Cobalt(II) aroylhydrazone complexes
  作者：M.F. Iskander、L. El Sayed、M.A. Lasheen

  DOI：10.1016/s0020-1693(00)91704-3

  日期：1976.1

  Abstract The reactions of some aroylhydrazones (HL) with cobalt(II) salts were investigated and chelates of the types [Co(HL) 2 X 2 ] and [Co(L) 2 ] were isolated. Analytical data, infrared studies, magnetic moments and solution spectra as well as some conductivity measurements were used to characterise these chelates. The [Co(HL) 2 X 2 ] chelates were found to possess octahedral configuration in solid

  摘要研究了某些芳香酰hydr（HL）与钴（II）盐的反应，并分离了[Co（HL）2 X 2]和[Co（L）2]类型的螯合物。使用分析数据，红外研究，磁矩和溶液光谱以及一些电导率测量来表征这些螯合物。发现[Co（HL）2 X 2]螯合物在固态下具有八面体构型，但在DMF溶液中解离。试图鉴定解离产物。暂时为中性[Co（L）2]螯合物指定了一个二聚体五坐标结构。
• Coordination compounds of hydrazine derivatives with transition metals. XIV. Nickel(II) chelates with bidentate aroylhydrazones and their reactions with heterocyclic bases
  作者：M.F. Iskander、S. Saddeck

  DOI：10.1016/s0020-1693(00)90911-3

  日期：1977.1

  neutral bis(ligand)nickel(II) chelates derived from some bidentate aroylhydrazones have been prepared and characterized. Whatever the solubility permits, the reaction of the neutral bis-(ligand)chelates, NiL 2 , with some heterocyclic bases were studied spectrophotometrically in benzene solution. The stability constants as well as the thermodynamic parameters (ΔG, ΔH, ΔS) for the adduct formation reaction

  摘要制备并表征了由一些双齿芳酰hydr衍生的阳离子和中性双（配体）镍（Ⅱ）螯合物。无论溶解度如何，均在苯溶液中分光光度法研究了中性双（配体）螯合物NiL 2与一些杂环碱的反应。测量了加合物形成反应的稳定性常数以及热力学参数（ΔG，ΔH，ΔS）。已从吡啶溶液中性双（配体）螯合物的结晶中分离出稳定的固态单，双和四吡啶鎓加合物。
• Fast Synthesis of <i>N</i>-Acylhydrazones Employing a Microwave Assisted Neat Protocol
  作者：Marta M. Andrade、Maria Teresa Barros

  DOI：10.1021/cc9001444

  日期：2010.3.8

  A variety of N-acylhydrazones were synthesized Under microwave irradiation within 2.5-10 min, starting from benzo, salicyloyl, and isonicotinic hydrazides. The protocol developed employs microwave irradiation in the absence of solvents and catalysts, leading to high yields. The results are reproducible in a 500 mg to 5 g scale.
• Agrawal, Taruna; Tiwari, Nirupama; Khan, M. H., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, # 6, p. 603 - 606
  作者：Agrawal, Taruna、Tiwari, Nirupama、Khan, M. H.、Nizamuddin

  DOI：——

  日期：——