Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors
作者:Hossam M. Hassan、Asmaa A. Sallam、Rabab Mohammed、Mohamed S. Hifnawy、Diaa T.A. Youssef、Khalid A. El Sayed
DOI:10.1016/j.bmc.2011.06.060
日期:2011.8
Sarcophine (1) is a bioactive cembranoid diterpene isolated from the RedSeasoftcoral Sarcophyton glaucum. Previous semisynthesis attempts resulted in decreased or complete loss of 1’s anticancer activity. Sarcophine and analogues showed antimigratory activity against breast and prostate cancer cell lines. This encouraged further semisynthestic optimizations to improve its activity and establish
Nickel/Photo-Cocatalyzed C(sp<sup>2</sup>)–H Allylation of Aldehydes and Formamides
作者:Pei Fan、Rui Wang、Chuan Wang
DOI:10.1021/acs.orglett.1c02938
日期:2021.10.1
nickel/photo-cocatalyzed C(sp2)–H allylation of aldehydes and formamides wherein both allyl acetates and allylalcohols can be used as the allylating agents. In this reaction, radical-type umpolung of the formyl moiety is enabled by tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst, whereas nickel serves to cleave the C–O bond of allyl acetates or allylalcohols. The synergistic effect