N-[3-carbamoyl-4-methyl-thien-2-yl]4-methyl-2-phenyl-1,2,3-triazole-5-carboxamide | 383381-87-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[3-carbamoyl-4-methyl-thien-2-yl]4-methyl-2-phenyl-1,2,3-triazole-5-carboxamide
• 英文别名: N-(3-carbamoyl-4-methylthiophen-2-yl)-5-methyl-2-phenyltriazole-4-carboxamide
• CAS: 383381-87-1
• 化学式: C₁₆H₁₅N₅O₂S
• 分子量: 341.393
• InChiKey: DQFDHGZLNRFFMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1294707A2

  公开（公告）日：2003-03-26
• US6414013B1
  申请人：——

  公开号：US6414013B1

  公开（公告）日：2002-07-02
• [EN] THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] DERIVES DE THIOPHENE ACTIFS EN TANT QU'INHIBITEURS DE KINASE, LEUR PROCEDE DE PREPARATION, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：PHARMACIA & UPJOHN SPA

  公开号：WO2001098290A2

  公开（公告）日：2001-12-27

  Compounds which are 3-aminocarbonyl-2-carboxamido-thiophene derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.