N-hydroxy-4-((4-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-1,2,3-triazol-1-yl)methyl)benzamide | 1267502-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-hydroxy-4-((4-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-1,2,3-triazol-1-yl)methyl)benzamide
• 英文别名: FNDR-20123；N-hydroxy-4-[4-(4-pyrrolidin-1-ylmethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-benzamide；FNDR-20123 free base；N-hydroxy-4-[[4-[4-(pyrrolidin-1-ylmethyl)phenyl]triazol-1-yl]methyl]benzamide
• CAS: 1267502-34-0
• 化学式: C₂₁H₂₃N₅O₂
• 分子量: 377.446
• InChiKey: MTAWGBVDXCFYOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  83.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• HISTONE DEACETYLASE INHIBITORS
  申请人：Selvakumar Natesan

  公开号：US20120101099A1

  公开（公告）日：2012-04-26

  The disclosure provides compounds of formula I and methods for preparation thereof. The compounds act as inhibitor of histone deacetylase.

  该披露提供了I式化合物及其制备方法。这些化合物作为组蛋白去乙酰化酶的抑制剂。
• [EN] HISTONE DEACETYLASE INHIBITORS<br/>[FR] INHIBITEURS DE L'HISTONE DÉSACÉTYLASE
  申请人：PORTSMOUTH TECHNOLOGIES LLC

  公开号：WO2011021209A1

  公开（公告）日：2011-02-24

  The disclosure provides compounds of formula I and methods for preparation thereof. The compounds act as inhibitor of histone deacetylase.

  该披露提供了I式化合物及其制备方法。这些化合物作为组蛋白去乙酰化酶的抑制剂。
• TREATMENT OF MALARIA USING HISTONE DEACETYLASE (HDAC) INHIBITORS
  申请人：FOUNDATION FOR NEGLECTED DISEASE RESEARCH

  公开号：US20220401418A1

  公开（公告）日：2022-12-22

  The present invention provides methods for treating malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising aN-hydroxy-4-((4-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-1,2,3-triazol-1-yl)methyl)benzamide.
• [EN] TREATMENT OF MALARIA USING HISTONE DEACETYLASE (HDAC) INHIBITORS<br/>[FR] TRAITEMENT DU PALUDISME AU MOYEN D'INHIBITEURS DE L'HISTONE DÉSACÉTYLASE (HDAC)
  申请人：FOUNDATION FOR NEGLECTED DISEASE RES

  公开号：WO2021090194A1

  公开（公告）日：2021-05-14

  The present invention provides methods for treating malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising aN-hydroxy-4-((4-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-1,2,3-triazol-1-yl)methyl)benzamide.