1-[4-(1,3-Benzoxazol-2-yl)-3-hydroxyphenyl]pyrrolidine-2,5-dione | 1312023-86-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[4-(1,3-Benzoxazol-2-yl)-3-hydroxyphenyl]pyrrolidine-2,5-dione
• CAS: 1312023-86-1
• 化学式: C₁₇H₁₂N₂O₄
• 分子量: 308.293
• InChiKey: PXCJGXJXAFSANF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氨基水杨酸 、 2-氨基苯酚 在 polyphosphoric acid 作用下， 以 乙醚 为溶剂， 反应 15.0h， 生成 1-[4-(1,3-Benzoxazol-2-yl)-3-hydroxyphenyl]pyrrolidine-2,5-dione
  参考文献：
  名称：

  Synthesis and photophysical properties of novel succinimidyl benzazole derivatives, evaluated by Candida albicans ATCC 10231 fluorescent staining

  摘要：

  New fluorescent succinimidyl benzazole derivatives were synthesised and successfully used to stain Candida albicans ATCC 10231 cells. The dyes were characterised by means of infrared, C-13 and H-1 NMR spectroscopies and elemental analysis. UV-Vis and steady-state fluorescence in solution were also applied to characterise their photophysical behaviour. The novel dyes were fluorescent in the yellow-green region by a phototautomerism in the excited state (ESIPT) with a large Stokes shift (9065-10962 cm(-1)). Dual fluorescence could also be observed depending on the solvent polarity. The present dyes were used as new probes by means of culture methodology or direct staining to study the micromorphology of Candida albicans. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.026