4-(5-cyclopentyl-1,2,4-oxadiazol-3-yl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide | 1330739-88-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(5-cyclopentyl-1,2,4-oxadiazol-3-yl)-5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide
• 英文别名: 4-(5-cyclopentyl-1,2,4-oxadiazol-3-yl)-5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-1,2-oxazole-3-carboxamide
• CAS: 1330739-88-2
• 化学式: C₂₂H₂₆N₄O₅
• 分子量: 426.472
• InChiKey: JUKZWRPFRVIRAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• 5-MEMBERED HETEROCYCLE DERIVATIVES AND MANUFACTURING PROCESS THEREOF
  申请人：Kang Jae-Hoon

  公开号：US20120309750A1

  公开（公告）日：2012-12-06

  Disclosed are a novel 5-membered heterocycle derivatives of Formula I, a tautomer, pharmaceutically acceptable salt, prodrug thereof and a pharmaceutical use thereof. The 5-membered heterocycle derivatives of Formula I, a tautomer, pharmaceutically acceptable salt, prodrug thereof and compositions containing them are useful for treating a tumor.

  本发明涉及一种新型的5-成员杂环衍生物，其化学式为I，其互变异构体，药学上可接受的盐，前药及其制药用途。化合物I的5-成员杂环衍生物，其互变异构体，药学上可接受的盐，前药及其组合物，用于治疗肿瘤。
• A NOVEL 5-MEMBERED HETEROCYCLE DERIVATIVES AND MANUFACTURING PROCESS THEREOF
  申请人：Il-Dong Pharm. Co., Ltd.

  公开号：EP2536714A2

  公开（公告）日：2012-12-26
• [EN] A NOVEL 5-MEMBERED HETEROCYCLE DERIVATIVES AND MANUFACTURING PROCESS THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS HÉTÉROCYCLIQUES À 5 CHAÎNONS ET LEUR PROCÉDÉ DE FABRICATION
  申请人：ILDONG PHARM CO LTD

  公开号：WO2011102660A2

  公开（公告）日：2011-08-25

  Disclosed herein are a novel 5-membered heterocycle derivatives represented by Formula I, a tautomer, pharmaceutically approved salts thereof, prodrug of this compound, or pharmaceutically use. Accordingly this prevent invention, a novel 5-membered heterocycle derivatives, a tautomer, pharmaceutically approved salt, or prodrug show antitumoral activity. Thus, this compounds are useful in the treatment of tumor.