(S)-2-(2-iodobenzamido)-N1,N4-diphenylsuccinamide | 956029-90-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(2-iodobenzamido)-N1,N4-diphenylsuccinamide
• CAS: 956029-90-6
• 化学式: C₂₃H₂₀IN₃O₃
• 分子量: 513.335
• InChiKey: CYPFJYMONKRQPR-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.06
• 重原子数：
  30.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  87.3
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (S)-2-(2-iodobenzamido)-N1,N4-diphenylsuccinamide 在 sodium tetrahydroborate 、 碘 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以76%的产率得到N2-(2-iodobenzyl)-N1,N4-diphenylbutane-1,2,4-triamine
  参考文献：
  名称：

  Synthesis of novel P-stereogenic phenylphosphonamides and their application to Lewis base-catalyzed asymmetric allylation of benzaldehyde

  摘要：

  The synthesis of novel P-stereogenic phenylphosphonamides 3 and 11 via an intramolecular nucleophilic substitution of P-stereogenic phosphoramide 8 is described. These compounds were used as chiral Lewis basic catalysts for the asymmetric allylation of benzaldehyde, providing the corresponding homoallylic alcohol derivatives in up to 54% ee. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.08.006
• 作为产物：
  描述：

  邻碘苯甲酰氯 、 (2R)-2-amino-N1,N4-diphenyl-succinamide 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以92%的产率得到(S)-2-(2-iodobenzamido)-N1,N4-diphenylsuccinamide
  参考文献：
  名称：

  Synthesis of novel P-stereogenic phenylphosphonamides and their application to Lewis base-catalyzed asymmetric allylation of benzaldehyde

  摘要：

  The synthesis of novel P-stereogenic phenylphosphonamides 3 and 11 via an intramolecular nucleophilic substitution of P-stereogenic phosphoramide 8 is described. These compounds were used as chiral Lewis basic catalysts for the asymmetric allylation of benzaldehyde, providing the corresponding homoallylic alcohol derivatives in up to 54% ee. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.08.006