2,3-Diphenyl-1-hydroxy-6-methylpyrrolo<1,2-a>pyrazine | 135613-54-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2,3-Diphenyl-1-hydroxy-6-methylpyrrolo<1,2-a>pyrazine
• 英文别名: 3-Methyl-6,7-diphenylpyrrolo[1,2-a]pyrazin-8-ol
• CAS: 135613-54-6
• 化学式: C₂₀H₁₆N₂O
• 分子量: 300.36
• InChiKey: VBFWFBMHKLEAHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  37.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  triethyloxonium fluoroborate 、 2,3-Diphenyl-1-hydroxy-6-methylpyrrolo<1,2-a>pyrazine 以 二氯甲烷 为溶剂， 反应 0.5h， 以100%的产率得到2,3-Diphenyl-1-ethoxy-6-methylpyrrolo<1,2-a>pyrazine
  参考文献：
  名称：

  Indolizines. 5. Preparation and structural assignments of azaindolizinols

  摘要：

  Diphenylcyclopropenone reacts smoothly with a variety of aromatic N-heterocycles to provide aza- and benzazaindolizinols. Although known in the literature, these compounds had been assigned incorrect structures. The preparation and physical properties of a number of derivatives, along with unequivocal assignments of structure based on a variety of NMR techniques, is described herein.

  DOI：

  10.1021/jo00019a024
• 作为产物：
  描述：

  2-甲基吡嗪 、 二苯基环丙烯酮 以 甲醇 为溶剂， 以45%的产率得到2,3-Diphenyl-1-hydroxy-6-methylpyrrolo<1,2-a>pyrazine
  参考文献：
  名称：

  Indolizines. 5. Preparation and structural assignments of azaindolizinols

  摘要：

  Diphenylcyclopropenone reacts smoothly with a variety of aromatic N-heterocycles to provide aza- and benzazaindolizinols. Although known in the literature, these compounds had been assigned incorrect structures. The preparation and physical properties of a number of derivatives, along with unequivocal assignments of structure based on a variety of NMR techniques, is described herein.

  DOI：

  10.1021/jo00019a024