2-(4-isopropoxyphenyl)-4-phenylimidazole | 1351974-39-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-isopropoxyphenyl)-4-phenylimidazole
• 英文别名: 5-phenyl-2-(4-propan-2-yloxyphenyl)-1H-imidazole
• CAS: 1351974-39-4
• 化学式: C₁₈H₁₈N₂O
• 分子量: 278.354
• InChiKey: VKFIYIHMSVHECX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯基丙醇水合物 、 4-异丙氧基苯甲醛 在 ammonium acetate 作用下， 以 甲醇 为溶剂， 生成 2-(4-isopropoxyphenyl)-4-phenylimidazole
  参考文献：
  名称：

  In vivo screening of diarylimidazoles as anticonvulsant agents

  摘要：

  In this study, the anticonvulsant activity evaluation of a series of new 2,4(1H)-diarylimidazoles, characterized by the presence of different substituents on the aryl rings, was described. The anticonvulsant activity profile of those compounds was determined by Maximal Electroshock Seizure (MES), subcutaneous Metrazol Seizure (scMet) tests, and 6-Hz seizure model, whereas their neurotoxicity was examined using rotarod test. The trifluoromethoxy derivative, obtained starting from phenylglyoxal, p-OCF3-benzaldehyde, and ammonium acetate in methanol (r.t.), exhibited a great ability to prevent the seizures induced in the 6-Hz test, becoming a new promising molecule to develop for the treatment of therapy-resistant partial seizures.

  DOI：

  10.1007/s00044-011-9869-9