1-methyl-3-[5-[4-(trifluoromethyl)pyrimidin-2-yl]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl]urea | 1209487-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-methyl-3-[5-[4-(trifluoromethyl)pyrimidin-2-yl]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl]urea
• CAS: 1209487-98-8
• 化学式: C₁₃H₁₃F₃N₆OS
• 分子量: 358.347
• InChiKey: UMZBMLHWEQZTMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• SUBSTITUENT-INCLUDING UREA COMPOUND
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3915558A1

  公开（公告）日：2021-12-01

  An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases. The present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. (Each symbol in Formula (1) has the same definition as that described in the specification.)

  本发明的目的是提供一种化合物，该化合物具有特定的化学结构，对 SIRT6 具有激活作用，可作为预防和治疗炎症性疾病的活性成分。本发明涉及一种由式（1）代表的化合物或其药学上可接受的盐。 式（1）中各符号的定义与说明书中所述的相同）。
• RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY
  申请人：Mitsuoka Yasunori

  公开号：US20110230472A1

  公开（公告）日：2011-09-22

  It is an object of the present invention to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused azole compound shown in the present specification, or a pharmaceutically acceptable salt thereof.
• [EN] SUBSTITUENT-INCLUDING UREA COMPOUND<br/>[FR] COMPOSÉ D'URÉE COMPRENANT UN SUBSTITUANT<br/>[JA] 置換基を有するウレア化合物
  申请人：DAIICHI SANKYO CO LTD

  公开号：WO2020153433A1

  公开（公告）日：2020-07-30

  本発明の課題は、SIRT6の活性化作用を有する特定の化学構造を有する、炎症性の疾患の予防及び治療のための有効成分として有用な化合物を提供することである。本発明は、式(1)の化合物、又は、その薬学上許容される塩に関する。 （式(1)中の記号はそれぞれ、明細書に記載された定義と同様である。）