N1-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide | 1224301-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N1-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide
• 英文别名: N-[(1R)-1-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]but-3-enyl]-4-methyl-N-prop-2-ynylbenzenesulfonamide
• CAS: 1224301-21-6
• 化学式: C₂₂H₂₉NO₄S
• 分子量: 403.543
• InChiKey: IRMHMAZNFOIBOJ-NHCUHLMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  64.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N1-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide 在 Grubbs catalyst first generation 作用下， 以 苯 为溶剂， 反应 24.0h， 以64%的产率得到(2R)-2-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-1-[(4-methylphenyl)sulfonyl]-5-vinyl-1,2,3,6-tetrahydropyridine
  参考文献：
  名称：

  Synthesis of chiral oxa- and azacycle-fused anthraquinone derivatives

  摘要：

  A convenient protocol for the synthesis of chiral pyran and piperidine ring-fused anthraquinone derivatives has been developed from (R)-2,3-O-cyclohexylidene-glyceraldehyde using sequential applications of enyne metathesis, Diels-Alder reaction and aromatization as key steps. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.02.001
• 作为产物：
  描述：

  N-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methyl-1-benzenesulfonamide 、 3-溴丙炔 在 sodium hydride 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 以89%的产率得到N1-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Synthesis of chiral oxa- and azacycle-fused anthraquinone derivatives

  摘要：

  A convenient protocol for the synthesis of chiral pyran and piperidine ring-fused anthraquinone derivatives has been developed from (R)-2,3-O-cyclohexylidene-glyceraldehyde using sequential applications of enyne metathesis, Diels-Alder reaction and aromatization as key steps. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.02.001

文献信息

• Synthesis of chiral oxa- and azacycle-fused anthraquinone derivatives
  作者：Tanmoy Biswas、Titas Biswas、Shital K. Chattopadhyay

  DOI：10.1016/j.tetasy.2010.02.001

  日期：2010.2

  A convenient protocol for the synthesis of chiral pyran and piperidine ring-fused anthraquinone derivatives has been developed from (R)-2,3-O-cyclohexylidene-glyceraldehyde using sequential applications of enyne metathesis, Diels-Alder reaction and aromatization as key steps. (C) 2010 Elsevier Ltd. All rights reserved.