N-(1,3-benzodioxol-5-ylmethyl)-N-{[1-butyl-4-(5-methylthien-2-yl)-2-phenyl-1H-imidazol-5-yl]methyl}butan-1-amine | 610287-39-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(1,3-benzodioxol-5-ylmethyl)-N-{[1-butyl-4-(5-methylthien-2-yl)-2-phenyl-1H-imidazol-5-yl]methyl}butan-1-amine
• 英文别名: N-(1,3-benzodioxol-5-ylmethyl)-N-[[3-butyl-5-(5-methylthiophen-2-yl)-2-phenylimidazol-4-yl]methyl]butan-1-amine
• CAS: 610287-39-3
• 化学式: C₃₁H₃₇N₃O₂S
• 分子量: 515.72
• InChiKey: VVBOAIXGPWZLKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• CARBONATES OF FENICOL ANTIBIOTICS
  申请人：Glinka Tomasz W.

  公开号：US20070155799A1

  公开（公告）日：2007-07-05

  Novel fenicol compounds having useful properties as antibiotic prodrugs, are provided, together with methods of making and using these new compounds.

  提供了具有作为抗生素前药有用特性的新颖费诺酮化合物，以及制备和使用这些新化合物的方法。
• Compositions containing prodrugs of florfenicol and methods of use
  申请人：Murthy V.S.N. Yerramilli

  公开号：US20050014828A1

  公开（公告）日：2005-01-20

  The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.

  本发明提供了用于给哺乳动物施用氟苯尼考的组合物和方法。该组合物包含氟苯尼考的前药，以及一种药用可接受的载体。在一个实施例中，前药是氟苯尼考的酯化形式。适当的前药的例子包括以下一个或多个的组合物：氟苯尼考乙酸酯，氟苯尼考丙酸酯，氟苯尼考丁酸酯，氟苯尼考戊酸酯，氟苯尼考己酸酯，氟苯尼考庚酸酯，氟苯尼考辛酸酯，氟苯尼考壬酸酯，氟苯尼考癸酸酯，氟苯尼考十一酸酯，氟苯尼考十二酸酯和氟苯尼考邻苯二甲酸酯。在另一个实施例中，前药经由一个或多个内源性酯酶的作用在体内转化为氟苯尼考。本发明还提供了新化合物、含有该化合物的药物组合物以及其施用方法。
• COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE
  申请人：Murthy Yerramilli V.S.N.

  公开号：US20080306152A1

  公开（公告）日：2008-12-11

  The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.

  本发明提供了一种向哺乳动物给予氟苯尼考的组合物和方法。该组合物包含氟苯尼考的前药，以药用载体为基础。在一种实施方式中，前药是氟苯尼考的酯化形式。适合的前药包括以下一种或多种的组合物：氟苯尼考醋酸盐、氟苯尼考丙酸盐、氟苯尼考丁酸盐、氟苯尼考戊酸盐、氟苯尼考己酸盐、氟苯尼考庚酸盐、氟苯尼考辛酸盐、氟苯尼考癸酸盐、氟苯尼考十一酸盐、氟苯尼考十二酸盐和氟苯尼考邻苯二甲酸盐。在另一种实施方式中，前药通过一个或多个内源性酯酶的作用在体内转化为氟苯尼考。本发明还提供了新化合物、含有该化合物的药物组合物和其给予方法。
• Florfenicol esters for treating bacterial infections
  申请人：IDEXX LABORATORIES, INC.

  公开号：EP2181706A2

  公开（公告）日：2010-05-05

  The present invention pertains to the use of a composition comprising a florfenicol ester and a pharmaceutically acceptable solvent wherein the florfenicol ester is selected from the group consisting of florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, and florfenicol dodecanoate; for the manufacture of a medicament for treating a bacterial infection that is susceptible to florfenicol in a bovine that can be administered as a single injection in an amount sufficient to treat the infection without requiring a second injection

  本发明涉及一种由氟苯尼考酯类和药学上可接受的溶剂组成的组合物的用途，其中氟苯尼考酯类选自由乙酸氟苯尼考、丙酸氟苯尼考、丁酸氟苯尼考、戊酸氟苯尼考、庚酸氟苯尼考、辛酸氟苯尼考、纳米氟苯尼考、癸酸氟苯尼考、十一酸氟苯尼考和十二酸氟苯尼考组成的组；用于制造一种治疗细菌感染的药物，这种细菌感染对氟苯尼考敏感，牛只需注射一次，注射量足以治疗感染而无需第二次注射。
• COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS
  申请人：NEUROGEN CORPORATION

  公开号：EP1490044A1

  公开（公告）日：2004-12-29