| 1394173-59-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• CAS: 1394173-59-1
• 化学式: C₁₉H₁₇BrO₆
• 分子量: 421.244
• InChiKey: PEJZRKDDUMWSCC-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  (2S,3R)-2,3-dibromo-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)propan-1-one 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Regioselective monobromination of (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-aryl-2-propen-1-ones using bromodimethylsulfonium bromide and synthesis of 8-bromoflavones and 7-bromoaurones

  摘要：

  A wide variety of monobrominated compounds 2a-I have been prepared in good yields from (E)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-aryl-2-propen-1-ones (1a-I) through regioselective ring bromination using 1.5 equiv of bromodimethylsulfonium bromide (BDMS) at room temperature. Similarly, some of the 2'-hydroxychalcones can be converted directly into tribromides 3 or dibromides 4 by employing 4.0 equiv of BDMS under different reaction conditions which in turn can be transformed into 8-bromoflavones and 7-bromoaurones on treatment with 0.2 M ethanolic KOH solution. Mild reaction conditions, good yields and no chromatographic separation are some of the salient features of the present protocol. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.122