2-cyclopropyl-5-(3-methoxy-phenyl)-thiazole-4-carboxylic acid | 1083282-88-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-cyclopropyl-5-(3-methoxy-phenyl)-thiazole-4-carboxylic acid
• 英文别名: 2-Cyclopropyl-5-(3-methoxy-phenyl)thiazole-4-carboxylic acid；2-cyclopropyl-5-(3-methoxyphenyl)-1,3-thiazole-4-carboxylic acid
• CAS: 1083282-88-5
• 化学式: C₁₄H₁₃NO₃S
• 分子量: 275.328
• InChiKey: NHIJFEKCTKVERA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  87.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS
  申请人：Aissaoui Hamed

  公开号：US20110263662A1

  公开（公告）日：2011-10-27

  The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R 1 , R 2 , R 3 , and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

  这项发明涉及式(I)的1,2-二胺基乙烯衍生物，其中R1、R2、R3和A如描述中所述，并且它们作为药物的用途，特别是作为促觉醒素受体拮抗剂。
• [EN] PIPERIDINE AND PYRROLIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE PIPÉRIDINE ET DE PYRROLIDINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009133522A1

  公开（公告）日：2009-11-05

  The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

  该发明涉及式（I）中的哌啶和吡咯烷化合物，其中A、B、n和X如描述中所述；其药学上可接受的盐，以及将这些化合物用作药物，特别是促醒素受体拮抗剂。
• 2-CYCLOPROPYL-THIAZOLE DERIVATIVES
  申请人：Aissaoui Hamed

  公开号：US20100222328A1

  公开（公告）日：2010-09-02

  The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

  该发明涉及公式（I）中所述的选择性2-环丙基噻唑衍生物，其中B、Y和R1如描述中所述；以及其盐，特别是药学上可接受的盐；以及将这些化合物用作药物，特别是促觉醒素受体拮抗剂的用途。
• PIPERIDINE AND PYROOLIDINE COMPOUNDS
  申请人：Aissaoui Hamed

  公开号：US20110039857A1

  公开（公告）日：2011-02-17

  The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

  该发明涉及式（I）中A、B、n和X如描述的哌啶和吡咯烷化合物；其药学上可接受的盐；以及将这些化合物用作药物的用途，特别是作为促觉醒素受体拮抗剂。
• PIPERIDINE AND PYRROLIDINE COMPOUNDS
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2318367A1

  公开（公告）日：2011-05-11