1'-[2(R)-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(5-fluoroindole-3-yl)-1-oxopropyl]-2,3-dihydro-6-fluorospiro[1H-indene-1,4'-piperidine]-3-acetic acid ethyl ester | 185525-16-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 1'-[2(R)-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(5-fluoroindole-3-yl)-1-oxopropyl]-2,3-dihydro-6-fluorospiro[1H-indene-1,4'-piperidine]-3-acetic acid ethyl ester
• 英文别名: ethyl 2-[1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-3-(5-fluoro-1H-indol-3-yl)propanoyl]-5-fluorospiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetate
• CAS: 185525-16-0
• 化学式: C₃₂H₃₈F₂N₄O₄
• 分子量: 580.675
• InChiKey: QJALZTXKRLCYGD-MLARANPPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  42
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Spiro piperidines and homologs promote release of growth hormone
  申请人：MERCK & CO. INC.

  公开号：EP0662481A1

  公开（公告）日：1995-07-12

  There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.

  已公开的某些新型化合物被鉴定为螺哌啶和同源物，它们能促进人和动物体内生长激素的释放。这种特性可用于促进食用动物的生长，使可食用肉类产品的生产更有效率；在人类中，可用于治疗以生长激素分泌不足为特征的生理或医学病症，如生长激素缺乏症儿童的身材矮小，以及治疗因生长激素的同化作用而得到改善的医学病症。此外，还公开了含有此类螺化合物作为活性成分的生长激素释放组合物。
• Growth-hormone secretagogues
  申请人：Elixir Pharmaceuticals, Inc.

  公开号：EP2389941A1

  公开（公告）日：2011-11-30

  Disclosed are methods of treating a disorder of the stomach, intestine or duodenum in a human subject. The method includes administering to the subject, a pharmaceutical composition comprising a compound that increases gastrointestinal motility (e.g., by modulating myenteric nerve activity) and/or induces the secretion or production of growth hormone.

  本发明公开了治疗人类胃、肠或十二指肠疾病的方法。该方法包括向受试者施用药物组合物，该药物组合物包含一种化合物，该化合物可增加胃肠道蠕动（例如，通过调节肠肌神经活动）和/或诱导生长激素的分泌或产生。
• Growth-Hormone Secretagogues
  申请人：Geesaman Bard J.

  公开号：US20080261873A1

  公开（公告）日：2008-10-23

  Disclosed are methods of treating a disorder of the stomach, intestine or duodenum in a human subject. The method includes administering to the subject, a pharmaceutical composition comprising a compound that increases gastrointestinal motility (e.g., by modulating myenteric nerve activity) and/or induces the secretion or production of growth hormone.
• US5578593A
  申请人：——

  公开号：US5578593A

  公开（公告）日：1996-11-26