3-(4-bromophenyl)-1-(2-((4-methoxyphenyl)ethynyl)phenyl)prop-2-yn-1-ol | 1370697-28-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 3-(4-bromophenyl)-1-(2-((4-methoxyphenyl)ethynyl)phenyl)prop-2-yn-1-ol
• 英文别名: 3-(4-Bromophenyl)-1-[2-[2-(4-methoxyphenyl)ethynyl]phenyl]prop-2-yn-1-ol
• CAS: 1370697-28-1
• 化学式: C₂₄H₁₇BrO₂
• 分子量: 417.302
• InChiKey: KIFPSPYIKIHECE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  丙醇 、 3-(4-bromophenyl)-1-(2-((4-methoxyphenyl)ethynyl)phenyl)prop-2-yn-1-ol 在 一氯化碘 作用下， 以99%的产率得到2-(4-bromophenyl)-1,3-diiodonaphthalene
  参考文献：
  名称：

  Highly Regioselective Synthesis of 1,3-Diiodonaphthalene Derivatives via a Sequential Cascade Iodocyclization

  摘要：

  A novel and flexible sequentially cascade iodocyclization for the synthesis of highly substituted 1,3-diiodinated naphthalene derivatives in up to 99% yield under mild conditions is reported. The dihalogenated moiety can be readily introduced into the naphthalenes in a position that is usually not easily functionalized.

  DOI：

  10.1021/ol300457c
• 作为产物：
  描述：

  4-乙炔基苯甲醚 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 乙基溴化镁 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.75h， 生成 3-(4-bromophenyl)-1-(2-((4-methoxyphenyl)ethynyl)phenyl)prop-2-yn-1-ol
  参考文献：
  名称：

  Highly Regioselective Synthesis of 1,3-Diiodonaphthalene Derivatives via a Sequential Cascade Iodocyclization

  摘要：

  A novel and flexible sequentially cascade iodocyclization for the synthesis of highly substituted 1,3-diiodinated naphthalene derivatives in up to 99% yield under mild conditions is reported. The dihalogenated moiety can be readily introduced into the naphthalenes in a position that is usually not easily functionalized.

  DOI：

  10.1021/ol300457c

文献信息

• Highly Regioselective Synthesis of 1,3-Diiodonaphthalene Derivatives via a Sequential Cascade Iodocyclization
  作者：Li-Jing Wang、Hai-Tao Zhu、Lei Lu、Fang Yang、Xue-Yuan Liu、Yong-Min Liang

  DOI：10.1021/ol300457c

  日期：2012.4.20

  A novel and flexible sequentially cascade iodocyclization for the synthesis of highly substituted 1,3-diiodinated naphthalene derivatives in up to 99% yield under mild conditions is reported. The dihalogenated moiety can be readily introduced into the naphthalenes in a position that is usually not easily functionalized.